The purpose of this study was an assessment of the proton 3D MR spectroscopy efficacy in diagnosis of primary glial brain tumors.
Material and methods. Sixty three patients aged from 20 to 60 years with primary glial brain tumors of varying degrees of malignancy were examined. The ratios of main metabolites indices were evaluated with following comparison with the metabolites obtained in gray and white matter of the opposite hemisphere.
The ratios of main metabolites: Cho/Cr, NAA/Cr, Cho/NAA showed significant (p <0.005) differences in the groups of patients with low and high grade gliomas.
Results. The obtained data proved the efficacy of the proton 3D MR-spectroscopy in predicting of the glial brain tumors malignancy.

Purpose of the study. To study the possibilities of 99mTc-MIBI single photon emission computed tomography (SPECT) at the monitoring of the preoperative treatment of patients with laryngeal and hypopharyngeal cancer. 

Materials and methods. The study included 28 pa tients with cancer of the larynx or laryngopharynx T2–3N0–2M0. 99mTc-MIBI SPECT was performed for all patients before and after preoperative treatment, semi-quantitative indices were calculated, according to SPECT 

Results. A statistically significant difference was observed in the retention index in patients with complete regression and stabilization. A lower retention index is observed in patients who had a clinically pronounced effect from preoperative treatment. The rate of radiotracer washout from the tumor was faster in patients with no effect of preoperative therapy. The level of radiopharmaceuticals uptake in the tumor tissue after preoperative treatment was significantly lower in the group of patients without progression than in the group of patients with progression of the disease. In addition, the accumulation of the radioindicator after preoperative chemotherapy increased in the group of patients with progression, and decreased in the group without progression.

Conclusion. The 99mTc-MIBI SPECT for tumor monitoring during treatment can be used. Semi-quantitative indices can be used as predictive criteria of results of preoperative treatment, as well as prognostic criteria for monitoring of such patients.

Carcinoma of the esophagus continues to be a malignant disease with a poor prognosis; the overall five-year survival rate ranges from 15 to 20%. Esophageal cancer is the eighth most common and the sixth most common cause of death among oncological diseases. The main task of esophageal cancer diagnostics is to assess the extent of the pathological process in order to determine the most optimal type of medical care. Currently, endoscopic ultrasonography (EUS) is considered to be the method of choice in determining the T-stage of the primary tumor. Moreover, several studies have shown the better results in N staging using EUS with TAB. At the same time, MRI of the esophagus is considered to be a technically challenging procedure because of difficulties in visualizing due to the motion artifacts. The motor and flow artifacts arising from the heartbeats and pulsations of the aorta and pulmonary vessels significantly reduce the quality of images. Nevertheless, the emergence in the last decade of some technical innovations can significantly reduce the impact of motion artifacts on image quality. For example, the effect of respiratory movements can be leveled using the proposed r-VIBE (radial VIBE) sequence, in which scanning and data collection occurs on the patient’s free breathing. However, in order to obtain high-quality images of the esophagus,(and make accurate staging of esophageal cancer, respectively) it is necessary to use different sequences; the scanning protocol must include T2-WI in several planes using high resolution sequences, DWI, and T1-WI with dynamic contrast enhancement. Application of new data collection technologies allowed to study esophagus on the expert level and to assess the local extent of the process accurately. Moreover, significant progress has been reached in assessing of N-stage in esophageal cancer with MRI in recent years. Unfortunately, a unified sequence protocol has not been developed yet and that makes it difficult to perform a statistical proper meta-analysis.
Creating conditions for esophageal cancer treatment indicates development of response predictors to the neoadjuvant chemoradiotherapy (nCRT), which would reliably determine the tumor response rate and likelihood before starting treatment, as well as creating reliable response criteria in the early periods after nCRT based on objective medical imaging data.
Another task is creatin of an artifact-decreasing sequence protocol, which would allow to determine the
extent of the lesion accurately. In addition, it is necessary to study the possibilities of MRI in the tumor staging, in comparison with the results obtained with EUS, CT, PET-CT in the form of a prospective study with a large sample of patients. 

Aim. To assess clinical and morpho-functional features of the heart in patients with congestive heart failure (CHF) after cardiac resynchronization therapy (CRT) depending on septal flash (SF).
Materials and methods. The study enrolled 60 patients (92.0% men, 8.0% women; mean age 54.5 ± 10.4 years; 70.0% had left bundle branch block (LBBB) with II-IV NYHA functional class CHF. SF (mechanical anomaly of interventricular septum (IVS) movement) is determined according to speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI). Patients were divided into two groups: with SF (I group, n = 10) and without SF (II group, n = 50).
Results. At baseline the groups did not differ in main clinical characteristics including QRS width and LBBB. Mechanical interventricular delay was higher in group I (65.5 ms [53.5; 95.5] vs 31.0 ms [15.0; 64.5]; р = 0.026). Basal segment of IVS longitudinal strain (LS) delay by STE (257.5 ms [156.3; 293.8] vs 323.5 ms [262.5; 377.8]; р = 0.024) and LS delay by TDI (204.0 ms [170.8; 260.3] vs 434.0 ms [370.0; 489.0]; р < 0.001) were significantly lower in group with SF. According to logistic regression a combination of LS apical segment of IVS by STE (HR 0.607; 95% Cl 0.369–0.989; р = 0.048) and LS delay basal segment of IVS by TDI (HR 0.969; 95% Cl 0.0945–0.993; р = 0.011) had a relationship with SF. According to ROC analysis sensitivity and specificity of this model in SF definition in patients with CRT were 87.5% and 86.5% (AUC = 0.939; p < 0.01). Mean changes in LV ESV (52.0 ml [32.5; 72.8] vs 19,0 ml [1.3; 40.0]; р = 0.002) and LV ejection fraction (EF) (13.0% [5.5; 18.8] vs 4.0% [2.0; 9.0]; р = 0.002) were significantly higher in patients with SF. All patients in group I had a superresponse to CRT (ESV LV decrease ≥30%); 42.0% patients in group II were superresponders (р < 0.001).
Conclusion. SF could be determined by STE and TDI. SF is associated with severe mechanical interventricular dyssynchrony and superresponse to CRT. Patients with SF have significantly better LV EF dynamics after CRT. 

Purpose. To determine the possibility of MSCT in the detection and diagnosis of complications of diverticulosis.
Materials and methods. MSCT was performed in the apparatus Aqullion Toshiba 64 with collimation of 0.5–1 mm with the multiphase contrast-enhanced and further multiplanar reformatting. The results of MSCT of abdominal organs in 2082 (100%) patients for 2016–2018 in GBUZ GKB im were analyzed. M.E. Zhadkevich, 841 (40%) – for emergency indications.
Results. Intestinal diverticula was detected in 239 (11%) patients. CT-signs of diverticulitis were found in 36 (1.7%) subjects: 19 (0.9%) women aged 54 years to 91 years and 17 (0.8%) men aged 27 to 88 years. When admitted to the hospital, all patients (36 people – 100%) with CT signs of diverticulitis complained of severe abdominal pain: with localization in the left iliac and suprapubic areas of 22 (61%) patients, 2 (5.5%) – in the right iliac and suprapubic areas, the remaining 12 (33.5%) patients complained of abdominal pain without a clear localization. Localization of diverticulitis in the sigmoid colon occurred in 22 (61%) cases, in the descending part of the colon – in 13 (36%). In 1 (3%) observation diverticulitis was detected in the terminal part of the jejunum.
The presence of perianth infiltrate took place – in 16 (44%) cases, with signs of abscedding – in 4 (11%), peritonitis was observed in 2 (5.5%) examined in combination with signs of intestinal obstruction. Perforation with the presence of a large amount of free gas was detected in 1 (3%) case, microperforation – in 12 (33.5%). A small amount of free fluid in the abdominal cavity was found in 18 (50%) patients. 
Conclusion. Timely diagnosis of complicated diverticular disease is crucial. MSCT has high sensitivity and specificity in the diagnosis of phlegmon and abscesses of the abdominal cavity, perforation of the intestinal wall, peritonitis, bleeding and intestinal obstruction.

Uncomplicated diverticula of the small intestine are asymptomatic, extremely rare in everyday practice and, most often, are detected already with the development of complications such as perforation and abscess formation. Diagnosis of complicated diverticula of the small intestine is difficult due to many other, more common causes of acute abdomen, insufficient use of the capabilities of the methods of radiation diagnosis, the lack of application and correct interpretation of the results of instrumental and special research methods. The article presents a clinical case of perforation of the jejunum diverticulum. The results of effective MDCT diagnosis and successful surgical intervention are presented: laparoscopic resection of the jejunum with the formation of the primary hardware intracorporeal enteroentero-anastomosis side by side.

Acute vascular pathology of the intestine is a collective concept that includes a number of conditions that develop due to insufficient supply of oxygen and nutrients to tissues. One of these conditions is an аcute mesenteric ischemia (AMIO). Diagnosis of AMIO reserves a lot of unresolved issues, in which CT angiography is the main method. Treatment of patients depends on the form of the course and stage of the disease. We present the case of a violation of the mesenteric blood circulation in a man against the background of poisoning by alcohol substitutes.

The article discusses the current principles of diagnostic radiology in theevaluation of suspected and verified cervical cancer (CC). Possibilities of magnetic resonance imaging in the primary diagnosis of the disease and effect evaluation of neoadjuvant treatment are described.Conditions and optimal MR-technique, as well asprinciples of data interpretation are discussed. The main prognostic factors for CC are consideredand, also, a brief review of treatment methods for various diseases stages is given.

The detailed an alysis of European Society of Urogenital Radiology (ESUR) and American College of Radiology (ACR) guide-linesforprostatecancer MRI system PI-RADS v.2.1 (2019) was presented. The several scattered theses of this system were structured in suchsectionsas: MRI data acquisition, interpretation, definition of lesion category for prostate cancer probability. This kind of systematization would be helpful for radiologists to master this newest guide-lines version. Finally, the differences between PI-RADS v.2.1 and the previousone were highlighted.

The purpose of the research is to find additional diagnostic tools that allow you to specify the nature of soft tissue lesions, differentiate between benign and malignant processes this localization.
Materials and methods. Using multiparametric echography surveyed 514 patients with malignant (243 or 55.7%) and benign (193 or 44.3%) tumor, as well as non-tumor (78 or 15.2%) diseases. In all cases, used while rendering, color Doppler mapping, power Doppler blood flow spectral characteristics of the studied zone changes. In 87 (16.9%) observations applied functional vascular test.
The results. Calculation of indicators diagnostic informative at diagnostics of sarcomas in relation to complex high without the use of vascular test and when you post data showed an increase in using it specificity and diagnostic accuracy stability in the total sensitivity of the entire complex. Sensitivity respectively amounted to 92.7% and 92.7%, specificity – 87.1% and 98.9%, accuracy-84.8% and 91.1% (inclusion in consideration of inflammatory processes led to the authenticity of the results obtained).
Conclusion. Vascular test improves diagnostic high informativeness of the complex, but it can be usefully applied to exclude non-tumorous changes and accounting possible differences in differentiation of different constituent parts neoplasm.

Aim of the study. We have carried out the synthesis of complex of Manganese(II) with dimercaptosuccinic acid (DMSA), applied the quantum chemistry analysis for evaluation of most stable form of the Mn- DMSA complex and studied it’s uptake and imaging properties in normal and tumoral tissues in veterinary patients (cats with tumors)
Material and methods. The synthesis of the 2.3-dimercaptosuccinic acid (COOH-CHSH-CHSH-COOH) has been carried out using modified technique proposed by A.I. Busev [Busev A.I. 1972]. Using phantoms filled in with 0.05 mM – 16 mM solutions of the agent we quantified the R1 relaxivity. Imaging properties of the 0.5 M solution of the Mn-(DMSA)2 were evaluated when performing the  contrastenhanced studies in veterinary patients (cats with adenofibrous tumors and angiofibromas, nine animals) using T1-w spin-echo mode.
Results. As result of quantum chemistry analysis it was shown that the most stable complex of Mn(II) with DMSA is the molecule Mn-(DMSA)2. The R1 relaxivity of the Mn-(DMSA)2 complex in the water solution was as high as 3.2 1/(mM*s). In normal control animals the Mn-(DMSA)2 provided highly intensive enhancement of renal parenchyma and mild enhancement of liver, spleen and bone marrow. In animals with tumors the Mn-(DMSA)2 enhanced the T1-w spin-echo images of angiofibromas and fibroadenomas in both peripheral (index of enhancement = 1.87 ± 0.09, p < 0.01) and central (index of enhancement = 1.59 ± 0.07, p < 0.01) parts of the tumor.
Conclusion. The imaging properties of the Mn-(DMSA)2 make an argue for real possibility of production of new non-Gadolinium paramagnetic contrast agents specific to tumors. Further study of the Mn-(DMSA)2 complex as paramagnetic contrast agent is of interest and useul.

In article the main dates of life and scientific creativity of professor V.A. Fanardzhyan are celebrated (1898–1976). It is shown that in 1926 he organized the Armenia's first X-ray radiological office, and in 1927 – department of a radiology at the Yerevan medical institute which he managed nearly 50 years. It is emphasized that since 1946 was the director of the Institute of a radiology and oncology of Ministry of Health care of the Armenian Soviet Socialist Republic organized by him. It is noted that after V.A. Fanardzhyan's death his name was appropriated to institute. In 1956–1963 it was elected the member of Presidium and the academician-secretary of office of medicobiological sciences of AN of the Armenian Soviet Socialist Republic. V.A. Fanardzhyan is the author of 150 works, including 20 monographs, guides and textbooks. It is shown that he established connection between changes of a form of a bulb of a duodenum and localization of an ulcer niche (“Fanardzhyan's regularity”). Its researches devoted to problems of radiodiagnosis of gastritis, stomach ulcer, a carcinoma of the stomach and gullet, fire injuries of a skull, heart diseases, respiratory organs, a large intestine, questions of use of bronchography, angiocardiography, fluorography, a rentgenokimografiya, problems of radiation therapy of cancer of various localizations, biological effect of ionizing radiation are analyzed. V.A. Fanardzhyan was elected by the honorary member of board of All-Union society of radiologists and radiologists, the chairman of the board of Society of radiologists, radiologists and oncologists of the Armenian Soviet Socialist Republic, “The medical radiology” of BME was an editor-in-chief of “The magazine of experimental and clinical medicine” of AN of the Armenian Soviet Socialist Republic, the editor of a redotdel. It is noted that the scientist is awarded with the Order of Lenin, awards of the Labour Red Banner and “Badge of Honour” and also various medals.