Mistakes in the Diagnosis of Gallbladder Cancer
Abstract
Objective. To determine the causes of misdiagnosis of gallbladder cancer (GBC). Materials and Methods. The results of examination and treatment of 34 patients GBC. Results. GBC was diagnosed in the majority of patients (92,8%) with stage T4, had spread to the liver from 78.9%, the liver metastases in 32.1%, the metastases in the lymph nodes in 39.2%. Sensitivity and specificity in the diagnosis GBC were 73.7% and 16.7% for ultrasound; 64.3% and 33.3% for X-ray CT; 69.2% and 0% for MRI; 71.4 % and 66.7% for CA -199; 94.1 % and 50% for the surgical evaluation. Lack of true positive MRI results are not possible to calculate the specificity. Low specificity of the methods due to the large number of false positives results - in (29.4%) patients. False positive results associated with inflammatory changes in the gallbladder and surrounding liver. False-negative results associated with the rapid spread of GBC on the liver, which is taken as primary liver cancer involving the gallbladder. Conclusion. Diagnosis GBC is a difficult task, even in advanced stages. Nevertheless, requires a comprehensive diagnosis using ultrasound, X-ray CT, MRI, determination of the level of CA 19-9 and biopsy
About the Authors
Tatiana Yurevna Danzanova
N.N. Blokhin Russian Oncological Centre of Russian academy of medical sciences
Russian Federation
Russian Federation
Galina Timofeevna Sinyukova
N.N. Blokhin Russian Oncological Centre of Russian academy of medical sciences
Russian Federation
Russian Federation
Yury Ivanovich Patyutko
N.N. Blokhin Russian Oncological Centre of Russian academy of medical sciences
Russian Federation
Russian Federation
Pavel Ivanovich Lepedatu
N.N. Blokhin Russian Oncological Centre of Russian academy of medical sciences
Russian Federation
Russian Federation
Bela Mihajlovna Medvedeva
N.N. Blokhin Russian Oncological Centre of Russian academy of medical sciences
Russian Federation
Russian Federation
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Review
For citations:
Danzanova T.Yu., Sinyukova G.T., Patyutko Yu.I., Lepedatu P.I., Medvedeva B.M. Mistakes in the Diagnosis of Gallbladder Cancer. Medical Visualization. 2014;(4):57-71. (In Russ.)
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