HEPATOCELLULAR ADENOMA WITH MALIGNANT TRANSFORMATION IN MALE PATIENT
https://doi.org/10.24835/1607-0763-2018-2-84-93
Abstract
Hepatocellular adenoma (HCA) is a rare primary benign tumor of the liver that generally occurs in women taking oral contraceptives. HCA in men is rare, and it is usually associated with anabolic steroid intake, glycogen storage disease I, III. There are some instances where HCA is induced by antiepileptic drugs. Malignant transformation is one of the complications of HCA, and it is 10 times more often in men than in women. We present a case, where a man, 23 years old, was taking antiepileptic drugs for a long time. The lesion in third liver segment was revealed under routine examination. MRI with hepatobiliary contrast agent was performed. Hepatocellular cancer (HCC) was suspected, however HCA was not excluded. The patient underwent resection of third liver segment. Histological and immunohistochemical examinations revealed that the tumor was β-catenin activated HCA with focus of well differentiated HCC. The article describes the clinical case and provides a brief literature review on this subject.
About the Authors
K. Kh. Lomovtseva
I.M. Sechenov 1st MSMU (Sechenov University).
Russian Federation
Russian Federation
Karina Kh. Lomovtseva – resident of Radiology Department.
Moscow.
Yu. S. Gal’china
A.V. Vishnevsky Institute of Surgery.
Russian Federation
Russian Federation
Yulia S. Galchina – resident of radiology department.
Moscow.
A. V. Glotov
A.V. Vishnevsky Institute of Surgery.
Russian Federation
Russian Federation
Andrey V. Glotov – pathologist of Pathology department.
Moscow.
D. V. Kalinin
A.V. Vishnevsky Institute of Surgery.
Russian Federation
Russian Federation
Dmitriy V. Kalinin – cand. of med. sci., chief of Pathology department.
Moscow.
A. V. Chzhao
A.V. Vishnevsky Institute of Surgery.
Russian Federation
Russian Federation
Alexey V. Chzhao – doct. of med. sci., professor, deputy director for scientific and clinical work.
Moscow.
Yu. A. Kovalenko
A.V. Vishnevsky Institute of Surgery.
Russian Federation
Russian Federation
Yury A. Kovalenko – cand. of med. sci., senior research of Department of liver, bile ducts and pancreas surgery.
Moscow.
G. G. Karmazanovsky
I.M. Sechenov 1st MSMU (Sechenov University); A.V. Vishnevsky Institute of Surgery.
Russian Federation
Russian Federation
Grigory G. Karmazanovsky – corresponding member of RAS, doct. of med. sci., professor, chief of the Radiology Department; professor of Department of Radiology in Institute of professional education.
Moscow.
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Review
For citations:
Lomovtseva K.Kh., Gal’china Yu.S., Glotov A.V., Kalinin D.V., Chzhao A.V., Kovalenko Yu.A., Karmazanovsky G.G. HEPATOCELLULAR ADENOMA WITH MALIGNANT TRANSFORMATION IN MALE PATIENT. Medical Visualization. 2018;(2):84-93. (In Russ.) https://doi.org/10.24835/1607-0763-2018-2-84-93
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