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Combined Positron-Emission and Computed Tomography in Diagnosis and Staging of Patients with Indolent non-Hodgkin’s Lymphoma

Abstract

Purpose. The aim was to investigate the role of positron-emission and computed tomography (PET/CT) with18F-FDG in the diagnosis and staging of patients with indolent non-Hodgkin’s lymphoma, to compare PET/CT findings with the results of computed tomography (CT) and proliferative activity of tumor cells. Material and methods. 49 consecutive patients with untreated indolent non-Hodgkin’s lymphoma were evaluated in our study. Conventional staging methods including CT as well as PET/CT with18F-FDG were performed for investigating lymph node and extranodal manifestation of the disease. Results. The sensitivities, specificities and diagnostic accuracies in diagnosis for lymphomatous involvement of nodal regions were 75.7%, 98.4% and 86.8% for PET/CT and 51%, 98.4% and 74.4% for CT The accuracy in detecting extranodal manifestation for PET/CT was 84.6% compared to 71.8% for CT. Disease staging by PET/CT and conventional diagnostic methods was identical in 75.5% of patients, 24.5% showed discordant results. PET/CT correctly resulted in a higher stage than CT in more than 18% (n = 9) of the patients. No significant difference was found between the SUVmax of the various types of indolent lymphoma (p = 0,065). The correlation of SUVmax and Ki-67 index was not statistically significant (r = 0,1, p = 0,7). Conclusion. PET/cT provides significantly more accurate information compared to CT for diagnosis and staging of patients with indolent non-Hodgkin’s lymphoma.

About the Authors

Malika Maratovna Khodzhibekova
Russian Research Centre of Radiology and Surgical Technologies
Russian Federation


Leonid Avramovich Tyutin
Russian Research Centre of Radiology and Surgical Technologies
Russian Federation


Nikolay Anatolevich Kostenikov
Russian Research Centre of Radiology and Surgical Technologies
Russian Federation


Nikolay Vasilevich Il’In
Russian Research Centre of Radiology and Surgical Technologies
Russian Federation


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Review

For citations:


Khodzhibekova M.M., Tyutin L.A., Kostenikov N.A., Il’In N.V. Combined Positron-Emission and Computed Tomography in Diagnosis and Staging of Patients with Indolent non-Hodgkin’s Lymphoma. Medical Visualization. 2014;(6):37-43. (In Russ.)

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ISSN 1607-0763 (Print)
ISSN 2408-9516 (Online)