Breast Cancer Hepatic Metastases after Transarterial Chemoembolization: the New Objective Response Criteria
Abstract
Objective: to evaluate the effect of transarterial chemoembolization (TACE) of breast cancer hepatic metastases, based on the calculation of changes in the volume of tumor tissue in metastatic lesions, and comparing this criteria with the RECIST criteria. Materials and methods. CT data of 21 patients with breast cancer metastatic liver lesions before and after treatment was analyzed. Evaluation of the treatment results was made separately for each patient according to RECIST criteria and according to criteria based on the indicator of tumor growth kinetics (reciprocal of doubling time, RDT). Comparative analysis of different criteria was conducted. Results. There was a statistically significant better performance of overall and disease-free survival in patients with an objective response by RDT indicator. The results indicate that the use of RECIST criteria may underestimate the objective response to treatment. Conclusion. The proposed tumor response evaluation criteria, based on the analysis of tumor growth kinetics, proves to be more accurate and respond adequately to the nature of morphological changes in the lesion and to the disease dynamics as well.
About the Authors
Andrey Alexandrovich Popov
Samara Regional Clinical Oncology Centre
Russian Federation
Russian Federation
Natalya Fedorovna Polyarush
Medical University “Reaviz”
Russian Federation
Russian Federation
Gennady Stepanovich Kozupitsa
Centre of Medicine and Valeology “Little”
Russian Federation
Russian Federation
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Review
For citations:
Popov A.A., Polyarush N.F., Kozupitsa G.S. Breast Cancer Hepatic Metastases after Transarterial Chemoembolization: the New Objective Response Criteria. Medical Visualization. 2016;(3):125-135. (In Russ.)
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