The Firstclinical Experiment with a new Domestic Radiopharmaceutical^99mTc-Aluminum Gamma-Oxideforimagingsentinel Lymph Nodesin Malignant Tumors

Purpose: To study the possibility of using new domestic radiopharmaceuticals based on^99mTc-aluminum gammaoxide to render the SLN in breast cancer and cervical cancer Materials and methods. The study included two groups of patients: I group - 34 (59.6%) patients with breast cancer (T1-2N0-1M0), II group - 23 (40.4%) patients with cervixcancer (T1A-2BN0-1M0). All patients were administered original radiopharmaceutical^99mTc-Al₂O₃ a day before the operationfor visualization of sentinel lymph nodes. Results. In the first group of patients identified 37 sentinel lymph nodes. The number of identified SLN per patient ranged from 1 to 2 (the average number of identified SLN - 1.08). The most frequently detected by us in SLE axillary region 36 (97.2%). The intensity of the inclusion of^99mTc-Al₂O₃ in SLE SpECT at 18 hours after administration is 7-11% of the injection site, with radiometry 17-31%. In the second group of sentinel lymph nodes were detected in all 23 patients of the second group. The intensity of the inclusion of^99mTc-Al₂O₃ in SLN with SpECT at 18 hours after administration is 3-6% of the injection site, with radiometry 14-26%. Conclusions. Designed on the basis of radiopharmaceutical^99mTc-Al₂O₃ 5-10 times more accumulated in the sentinel lymph nodes, firmly seating them, without further redistribution around the lymphatic collectors. Sensitivity and specificity of application of^99mTc-Al₂O₃ with single photon emission computed tomography and intraoperative radiometric display sentinel lymph nodes was 100%.

радионуклидная диагностика, сторожевые лимфатические узлы, рак молочной железы, рак шейки матки, radionuclide diagnosis, sentinel lymph nodes, breast cancer, cervical cancer

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