Unilateral Megalencephaly Prenatal Diagnostics

Abstract

The information on the developmental brain malformation megalencephaly is absent in modern manuals on prenatal diagnostics. There are data in the literature on diagnostics of megalencephaly in children. The cerebral gigantism (megalencephaly) is explained by the increase of cerebral parenchima, which can occur in response to several reasons. It has been argued that this abnormality is connected with initial disorders in neuronal proliferation. The body size of these children is not compatible with the large size of the head. This was the reason of the name - cerebral gigantism. This picture harmonizes with prosilient (porrect) forehead, Gothis palate, hypertelorism, dolichocephaly, large hands and legs. Unilateral megalencephaly - is a hamarto-shaped local or total increase of cerebral hemisphere with the defects of neutrons migration. Clinically unilateral megalencephaly is early evident by medicamentally resistant epilepsy, hemiplegia and hard subpar growth curve (arrested development). Assessments of two medical cases of prenatal determined diagnosis “unilateral megalencephaly” with emphasis on possibility of diagnostics are presented.