A complex of methods of radiation diagnostics in a patient with multiple myeloma (clinical case)
https://doi.org/10.24835/1607-0763-2020-4-133-145
Abstract
The article presents the possibilities of the complex application of methods of radiation diagnostics: bone x-ray, dual-energy X-ray absorptiometry, computed tomography, positron emission tomography combined with computed tomography using fluorodeoxyglucose labeled with 18-fluorine (PET/CT with 18F-FDG) in a patient with multiple myeloma, which was treated in the amount of high-dose therapy with autologous transplantation of hematopoietic stem cells. The diagnosis was established immunohistochemically. The use of these methods allowed us to dynamically assess the pathological changes characteristic of multiple myeloma.
About the Authors
E. V. KryukovRussian Federation
Evgeny V. Kryukov – Corresponding Member of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Head
3, Gospital`naya square, Mosсow 105094, Russian Federation
V. N. Troyan
Russian Federation
Vladimir N. Troyan – Doct. of Sci. (Med.), Professor, Head of the center for radiation diagnosis
3, Gospital`naya square, Mosсow 105094, Russian Federation
O. A. Rukavitsyn
Russian Federation
Oleg A. Rukavitsyn – Doct. of Sci. (Med.), Professor, Head of the Hematology Center
3, Gospital`naya square, Mosсow 105094, Russian Federation
S. A. Alekseev
Russian Federation
Sergey A. Alekseev – Radiologist of the department of computed tomography and magnetic resonance imaging of PET center
3, Gospital`naya square, Mosсow 105094, Russian Federation
Phone: +7-962-377-08-75
S. I. Kurbanov
Russian Federation
Sergei I. Kurbanov – Cand. of Sci. (Med.), Head of PET Center
3, Gospital`naya square, Mosсow 105094, Russian Federation
V. P. Pop
Russian Federation
Vasily P. Pop – Cand. of Sci. (Med.), Head of the Department of High-Dose Chemotherapy and Myelo-Transplantation
3, Gospital`naya square, Mosсow 105094, Russian Federation
S. V. Kozyrev
Russian Federation
Sergey V. Kozyrev – Cand. of Sci. (Med.), Head of the X-ray department
3, Gospital`naya square, Mosсow 105094, Russian Federation
E. R. Sapelnikova
Russian Federation
Elmira R. Sapelnikova – Cand. of Sci. (Med.), head of the Department of Endocrinology
8a, Bolshaya Olen’ya str., 107014 Moscow, Russian Federation
References
1. Pop V.P., Rukavitsin O.A. et al. Multiple myeloma and related diseases. 3rd ed. reslave. and add. M.: GEOTARMedia, 2016. 224 p. (In Russian)
2. Sakhin V.T., Madzhanova E.R., Kryukov E.V., Sotnikov A.V., Gordienko A.V., Rukavitsyn O.A. Anemia of Chronic Disease: Key Mechanisms of Pathogenesis in Patients with Malignancies and Feasible Classification Approaches. Clinical oncohematology. 2019; 12 (3): 344–349. (In Russian) https://doi.org/10.21320/2500-2139-2019-12-3-344-349
3. Rajkumar S., Kumar S. Multiple myeloma: diagnosis and treatment. Mayo Clin. Proc. 2016; 91 (1): 101–119. https://doi.org/10.1016/j.mayocp.2015.11.007.
4. Mariette X., Khalifa P., Ravaud P., Frija J., Laval-Jeantet M., Chastang C., Brouet J.C., Fermand J.P. Bone densitometry in patients with multiple myeloma. Am. J. Med. 1992; 6 (93): 595–598. https://doi.org/10.1016/0002-9343(92)90190-m .
5. Muchtar E., Dagan A., Robenshtok E., Shochat T., Oniashvili N., Amitai I., Raanani P., Magen H. Bone mineral density utilization in patients with newly diagnosed multiple myeloma. Hematological Oncology. 2017; 4 (35): 703–710. https://doi.org/10.1002/hon.2303
6. Durie B.G., Harousseau J.L., Miguel J.S., Bladé J., Barlogie B., Anderson K., Gertz M., Dimopoulos M., Westin J., Sonneveld P., Ludwig H., Gahrton G., Beksac M., Crowley J., Belch A., Boccadaro M., Cavo M., Turesson I., Joshua D., Vesole D., Kyle R., Alexanian R., Tricot G., Attal M., Merlini G., Powles R., Richardson P., Shimizu K., Tosi P., Morgan G., Rajkumar S.V.; International Myeloma Working Group. International uniform response criteria for multiple myeloma. Leukemia. 2006; 9 (20): 1467–1473. https://doi.org/10.1038/sj.leu.2404284
7. Troyan V.N., Rukavitsyn O.A., Kryukov E.V., Kozyrev S.V., Pop V.P., Simashova P.I., Sapelnikova E.R., Daragan- Sushchov I.G. The possibilities of dual-energy X-ray absorptiometric densitometry in monitoring the dynamics of treatment of multiple myeloma. Military Medical Journal. 2018; 339 (11): 58–59. (In Russian)
8. Kryukov E.V., Troyan V.N., Rukavitsyn O.A., Kozyrev S.V., Daragan-Sushchov I.G., Pop V.P., Alekseev S.A., Sapelnikova E.R. Densitometry as a monitoring method in the treatment of patients with multiple myeloma. Medical Visualization. 2018; 22 (5): 106–113. (In Russian) https://doi.org/10.24835/1607-0763-2018-5-106-113
9. Bier G., Kloth C., Schabel C., Bongers M., Nikolaou K., Horger M. Vertebral lesion distribution in multiple myeloma-assessed by reduced-dose whole-body MDCT. Skeletal Radiol. 2016; 1 (45): 127–133. https://doi.org/10.1007/s00256-015-2268-4
10. Nanni C., Zamagni E., Farsad M., Castellucci P., Tosi P., Cangini D., Salizzoni E., Canini R., Cavo M., Fanti S. Role of 18F-FDG PET/CT in the assessment of bone involvement in newly diagnosed multiple myeloma: preliminary results. Eur. J. Nuclear Med. Molec. Imaging. 2006; 5 (33): 525–531. https://doi.org/10.1007/s00259-005-0004-3
11. Durie B.G., Waxman A.D., D'Agnolo A., Williams C.M. Whole-Body 18F-FDG PET Identifies High-Risk Myeloma. J. Nuclear Med. 2002; 11 (43): 1457–1463.
Review
For citations:
Kryukov E.V., Troyan V.N., Rukavitsyn O.A., Alekseev S.A., Kurbanov S.I., Pop V.P., Kozyrev S.V., Sapelnikova E.R. A complex of methods of radiation diagnostics in a patient with multiple myeloma (clinical case). Medical Visualization. 2020;24(4):133-145. (In Russ.) https://doi.org/10.24835/1607-0763-2020-4-133-145