Computed tomography of lung infections in patients with lymphoproliferative diseases after chemotherapy
https://doi.org/10.24835/1607-0763-2020-1-59-67
Abstract
Objective: to determine CT features of pneumonia depending on the etiological agent in patients with LHP
after chemotherapy.
Materials and methods. 52 patients with LPD, who developed pneumonia, underwent chest CT. In all patients, the causative agent of lower respiratory tract infection was verified by microbiological diagnostic methods.
Results. In the first 48 hours from the onset of the viral pneumonia, thickening of the interlobular septa and of peribronchial interstitium, part-solid and solid nodules, and hydropericardium (p < 0.01) were detected. After 48 hours, ground glass opacity, Intralobular septal thickening, “crazy-paving” pattern and hydropericardium were more often detected (p < 0.001). In the first 48 hours from the onset of invasive pulmonary mycosis, a halo sign (p < 0.01) and the prevalence of changes in the upper parts of the lungs (p < 0.05) were detected. After 48 hours, halo sign (p <0.01), a random distribution of nodules and solid nodules (p < 0.05) were detected.
Conclusion. Viral or fungal etiology of lower respiratory tract infection can be excluded according to CT data with sufficient certainty, and that is undoubtedly a fundamental reason for changing further treatment tactics in such patients.
About the Authors
A. B. Kosichkina
N.N. Petrov National Medical Research Center of Oncology
Russian Federation
radiologist at the Department of Radiation Diagnostics, Junior Researcher at the Scientific Department of Diagnostic and Interventional Radiology
68, Leningradskaya str., Pesochny, Saint Petersburg, 197758, Russian Federation
Russian Federation
radiologist at the Department of Radiation Diagnostics, Junior Researcher at the Scientific Department of Diagnostic and Interventional Radiology
68, Leningradskaya str., Pesochny, Saint Petersburg, 197758, Russian Federation
A. V. Mishchenko
N.N. Petrov National Medical Research Center of Oncology
Russian Federation
Russian Federation
Doct. of Sci. (Med.), Deputy Chief Physician for Diagnostics, State Clinical Hospital No. 1 DZM, Professor, Professor of the Scientific Clinical and Educational Center “Radiation Diagnostics and Nuclear Medicine” of St. Petersburg State University, Leading Researcher
68, Leningradskaya str., Pesochny, Saint Petersburg, 197758, Russian Federation
S. A. Kuleva
N.N. Petrov National Medical Research Center of Oncology
Russian Federation
Doct. of Sci. (Med.), Head of the Department of Chemotherapy and combined treatment of pediatric malignancies, lead researcher at the Department of innovative methods of therapeutic oncology and rehabilitation
68, Leningradskaya str., Pesochny, Saint Petersburg, 197758, Russian Federation
Russian Federation
Doct. of Sci. (Med.), Head of the Department of Chemotherapy and combined treatment of pediatric malignancies, lead researcher at the Department of innovative methods of therapeutic oncology and rehabilitation
68, Leningradskaya str., Pesochny, Saint Petersburg, 197758, Russian Federation
V. V. Danilov
N.N. Petrov National Medical Research Center of Oncology
resident at the Department of Radiology
68, Leningradskaya str., Pesochny, Saint Petersburg, 197758, Russian Federation
resident at the Department of Radiology
68, Leningradskaya str., Pesochny, Saint Petersburg, 197758, Russian Federation
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Review
For citations:
Kosichkina A.B., Mishchenko A.V., Kuleva S.A., Danilov V.V. Computed tomography of lung infections in patients with lymphoproliferative diseases after chemotherapy. Medical Visualization. 2020;24(1):59-67. (In Russ.) https://doi.org/10.24835/1607-0763-2020-1-59-67
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