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Биохимические основы визуализации при позитронной эмиссионной томографии в онкологии. Часть 1

https://doi.org/10.24835/1607-0763-2019-4-114-130

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Аннотация

Настоящая статья содержит обзор основных литературных данных, посвященных биохимическим основам клинического применения позитронной эмиссионной томографии - одной из наиболее перспективных технологий лучевой визуализации в онкологии. В первой части рассмотрены особенности биокинетики метаболических радиофармацевтических препаратов, таких как 18F-фтордезоксиглюкоза, радиомеченые маркеры липидного обмена 11С- и 18F-холин, 11C-ацетат, а также аналоги аминокислот 18F-дигидроксифенилаланин, 11C метионин, 18F-фторэтилтирозин, 11C-триптофан, 18F-флуцикловин. Кратко представлены результаты исследований, посвященных оценке эффективности, основные показания к применению, а также перспективные научные разработки в данной отрасли.

Об авторах

А. В. Леонтьев
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия

канд. мед. наук, заведующий отделением радионуклидной диагностики

125284, Москва, 2-й Боткинский проезд, д. 3

Тел.: +7-495-945-87-18



Н. А. Рубцова
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия
доктор мед. наук, руководитель отдела лучевой диагностики


А. И. Халимон
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия
врач-рентгенолог отделения КТ и МРТ


Г. Ф. Хамадеева
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия


М. Т. Кулиев
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия

клинический ординатор кафедры онкологии, радиотерапии и пластической хирургии лечебного факультета ФГАОУ ВО Первый МГМУ имени И.М. Сеченова (Сеченовский Университет) на базе отделения радионуклидной диагностики



И. В. Пылова
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия
канд. мед. наук, врач-радиолог отделения радионуклидной диагностики


Т. Н. Лазутина
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия
канд. мед. наук, врач-радиолог отделения радионуклидной диагностики


А. А. Костин
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия
доктор мед. наук, профессор, первый заместитель генерального директора


А. Д. Каприн
МНИОИ имени П.А. Герцена – филиал ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России
Россия

академик РАН, доктор мед. наук, профессор, главный уролог РАН, заслуженный врач РФ, генеральный директор



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Для цитирования:


Леонтьев А.В., Рубцова Н.А., Халимон А.И., Хамадеева Г.Ф., Кулиев М.Т., Пылова И.В., Лазутина Т.Н., Костин А.А., Каприн А.Д. Биохимические основы визуализации при позитронной эмиссионной томографии в онкологии. Часть 1. Медицинская визуализация. 2019;(4):114-130. https://doi.org/10.24835/1607-0763-2019-4-114-130

For citation:


Leontyev A.V., Rubtsova N.A., Khalimon A.I., Khamadeeva G.F., Kuliev M.T., Pylova I.V., Lazutina T.N., Kostin A.A., Kaprin A.D. Biochemical basics of imaging in positron emission tomography in oncology. Part 1. Medical Visualization. 2019;(4):114-130. (In Russ.) https://doi.org/10.24835/1607-0763-2019-4-114-130

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