Use of ^99mTc-MIBI spect in estimating the efficiency pre-operative treatment of the larynx and laryngopharynx cancer

Purpose of the study. To study the possibilities of 99mTc-MIBI single photon emission computed tomography (SPECT) at the monitoring of the preoperative treatment of patients with laryngeal and hypopharyngeal cancer. 

Materials and methods. The study included 28 pa tients with cancer of the larynx or laryngopharynx T2–3N0–2M0. 99mTc-MIBI SPECT was performed for all patients before and after preoperative treatment, semi-quantitative indices were calculated, according to SPECT 

Results. A statistically significant difference was observed in the retention index in patients with complete regression and stabilization. A lower retention index is observed in patients who had a clinically pronounced effect from preoperative treatment. The rate of radiotracer washout from the tumor was faster in patients with no effect of preoperative therapy. The level of radiopharmaceuticals uptake in the tumor tissue after preoperative treatment was significantly lower in the group of patients without progression than in the group of patients with progression of the disease. In addition, the accumulation of the radioindicator after preoperative chemotherapy increased in the group of patients with progression, and decreased in the group without progression.

Conclusion. The 99mTc-MIBI SPECT for tumor monitoring during treatment can be used. Semi-quantitative indices can be used as predictive criteria of results of preoperative treatment, as well as prognostic criteria for monitoring of such patients.

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