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Use of 99mTc-MIBI spect in estimating the efficiency pre-operative treatment of the larynx and laryngopharynx cancer

https://doi.org/10.24835/1607-0763-2019-3-19-27

Abstract

Purpose of the study. To study the possibilities of 99mTc-MIBI single photon emission computed tomography (SPECT) at the monitoring of the preoperative treatment of patients with laryngeal and hypopharyngeal cancer. 

Materials and methods. The study included 28 pa tients with cancer of the larynx or laryngopharynx T2–3N0–2M0. 99mTc-MIBI SPECT was performed for all patients before and after preoperative treatment, semi-quantitative indices were calculated, according to SPECT 

Results. A statistically significant difference was observed in the retention index in patients with complete regression and stabilization. A lower retention index is observed in patients who had a clinically pronounced effect from preoperative treatment. The rate of radiotracer washout from the tumor was faster in patients with no effect of preoperative therapy. The level of radiopharmaceuticals uptake in the tumor tissue after preoperative treatment was significantly lower in the group of patients without progression than in the group of patients with progression of the disease. In addition, the accumulation of the radioindicator after preoperative chemotherapy increased in the group of patients with progression, and decreased in the group without progression.

Conclusion. The 99mTc-MIBI SPECT for tumor monitoring during treatment can be used. Semi-quantitative indices can be used as predictive criteria of results of preoperative treatment, as well as prognostic criteria for monitoring of such patients.

About the Authors

A. A. Medvedeva
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

cand. of med. sci., senior researcher of the department of nuclear medicine

5 Kooperativny str., Tomsk, 634050, Russia

Phone: 8-903-952-45-75



V. I. Chernov
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

doct. of med. sci., Professor, Head of the department of nuclear medicine

5 Kooperativny str., Tomsk, 634050, Russia



R. V. Zeltchan
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

cand. of med. sci., department of nuclear medicine

5 Kooperativny str., Tomsk, 634050, Russia



I. G. Sinilkin
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

cand. of med. sci., senior researcher of the department of nuclear medicine

5 Kooperativny str., Tomsk, 634050, Russia



O. D. Bragina
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

cand. of med. sci., senior researcher at the department of nuclear medicine

5 Kooperativny str., Tomsk, 634050, Russia



E. L. Choynzonov
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

doct. of med. sci., Member of Russian Academy of Sciences, Head

5 Kooperativny str., Tomsk, 634050, Russia



S. Yu. Chizhevskaya
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

PhD MD, senior researcher of the department of head and neck tumor

5 Kooperativny str., Tomsk, 634050, Russia



Yu. V. Belevich
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

MD, senior researcher of the chemotherapy department

5 Kooperativny str., Tomsk, 634050, Russia



V. E. Gol’dberg
Tomsk National Research Medical Center of the Russian Academy of Sciences Cancer Research institute
Russian Federation

doct. of med. sci., Head of the chemotherapy department

5 Kooperativny str., Tomsk, 634050, Russia



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Review

For citations:


Medvedeva A.A., Chernov V.I., Zeltchan R.V., Sinilkin I.G., Bragina O.D., Choynzonov E.L., Chizhevskaya S.Yu., Belevich Yu.V., Gol’dberg V.E. Use of 99mTc-MIBI spect in estimating the efficiency pre-operative treatment of the larynx and laryngopharynx cancer. Medical Visualization. 2019;(3):19-27. (In Russ.) https://doi.org/10.24835/1607-0763-2019-3-19-27

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