A case of pulmonary langerhans' cell histiocytosis mimicking osteosarcoma pulmonary metastases (clinical case)
https://doi.org/10.24835/1607-0763-2019-2-44-48
Abstract
Langerhans cell histiocytosis is a clonal neoplastic process characterized by cell proliferation of the Langerhans type, with the expression of CD1a, CD207 and S100 proteins and the presence of Birbek granules. We present a case of a 31-year-old woman with a verified osteosarcoma of the proximal epimetaphysis of the left tibia. Also she has multiple thin-walled cysts and foci in the lungs. The case is interesting for the rare combination of osteosarcoma of the bone and pulmonary histiocytosis. This case show that foci in lungs can simulates metastatic disease according to computed tomography (CT). Multidisciplinary approach of pathologist, oncologist and radiologist help revealed diagnose.
About the Authors
P. S. Kalinin
National Medical Research Center of Oncology named after N.N. Petrov
Russian Federation
Russian Federation
Petr S. Kalinin – cand. of med. sci., radiologist at the Department of Radiology
68 Leningradskaya str., Pesochny, 197758, St. Petersburg
V. A. Kushnarev
National Medical Research Center of Oncology named after N.N. Petrov
Russian Federation
Vladimir A. Kushnarev – research fellow, laboratory of tumor morphology, pathologist at the department of pathology
Russian Federation
Vladimir A. Kushnarev – research fellow, laboratory of tumor morphology, pathologist at the department of pathology
A. H. Balkarov
National Medical Research Center of Oncology named after N.N. Petrov
Russian Federation
Alim Kh. Balkarov– resident at the Department of Radiology
Russian Federation
Alim Kh. Balkarov– resident at the Department of Radiology
A. S. Artemyeva
National Medical Research Center of Oncology named after N.N. Petrov
Russian Federation
Anna S. Artemyeva – cand. of med. sci., Head of laboratory of tumor morphology, pathologist at the department of pathology
Russian Federation
Anna S. Artemyeva – cand. of med. sci., Head of laboratory of tumor morphology, pathologist at the department of pathology
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Review
For citations:
Kalinin P.S., Kushnarev V.A., Balkarov A.H., Artemyeva A.S. A case of pulmonary langerhans' cell histiocytosis mimicking osteosarcoma pulmonary metastases (clinical case). Medical Visualization. 2019;(2):44-48. (In Russ.) https://doi.org/10.24835/1607-0763-2019-2-44-48
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