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Qualitative analysis of contrast-enhanced ultrasound in differential diagnosis of breast lesions

https://doi.org/10.24835/1607-0763-2019-1-87-96

Abstract

The objective. Revelation of informative markers of qualitative analysis CEUS in the differential diagnosis of breast lesions, determination of effectiveness CEUS in the breast cancer examination.

Materials and methods. The work is based on the results of a retrospective comparison ultrasound data with the histological results conducted in 145 women with breast lesions at the age of 17-71 years (average age was 45.5 years) from December 2017 until November 2018 year.

Results. Statistical analysis of markers of qualitative assessment CEUS showed that more important markers in the differential diagnosis were - indicators of definition of the boundaries of lesion during CEUS (Se 79,27 Sp 63,41); the velocity of accumulation of contrast agent (Se 78,05 Sp 80,95); wash-out velocity from lesion (Se 68,29 Sp 95,24).

Conclusion. Qualitative data analysis of CEUS provides to detail of breast lesions and surround tissues vascular architecture, improves differential diagnosis of breast tumors, which allows to reduce the number of additional methods of examination and biopsies, predict the volume of surgical and complex treatment.

About the Authors

Yu. V. Bikeev
National Research Center for Obstetrics, Gynecology and Perinatology
Russian Federation

Yuri V. Bikeev - doctor of ultrasound diagnostics department.

Academica Oparina str., 4, Moscow, Russia, 117997, Phone: +7-903-713-03-03


Competing Interests: No conflict of interest


A. N. Sencha
National Research Center for Obstetrics, Gynecology and Perinatology
Russian Federation

Aleksandr N. Sencha - doct. of med. sci., Head of radiology department.

Moscow


Competing Interests: No conflict of interest


V. V. Radionov
National Research Center for Obstetrics, Gynecology and Perinatology
Russian Federation

Valeriy V. Rodionov - doct. of med. sci., Professor, Head of breast diseases department.

Moscow

Competing Interests: No conflict of interest


L. B. Shubin
Yaroslavl’ state medical university
Russian Federation

Leonid B. Shubin - cand. of med. sci., Associate Professor, division of pathology.

Yaroslavl


Competing Interests: No conflict of interest


E. A. Sencha
Medical Diagnostic Center No. 9
Russian Federation

Ekaterina A. Sencha - doctor of ultrasound diagnostics department.

Moscow


Competing Interests: No conflict of interest


References

1. Xu H.-X., Lu M.-D. The current status of contrast-enhanced ultrasound in China. J. Med. Ultrason. (2001) 2010; 37: 97-106. https://doi.org/10.1007/s10396-010-0264-9

2. Radzinskiy V.E., Ordiyants I.M. Comprehensive approach to the diagnosis and treatment of gynecological and mammological diseases and disorders. Mammolog. 2005; 1: 12-16. (In Russian)

3. Malignant neoplasms in Russia in 2016 (morbidity and mortality). A.D. Kaprin, V.V. Starinskiy eds. M.: PA. Hertsen Moscow Oncology Research Center, 2018. 250 p. (In Russian)

4. Vysotskaya I.V., Zabolotskaya N.V., Letyagin V.P., Laktionov K.P, Chubarova K.A., Levkina N.V. Modern capabilities of breast pathology diagnostics. Tumors of Female Reproductive System. 2015; 11 (1): 18-26. (In Russian)

5. Li Q., Hu M., Chen Z., Li C., Zhang X., Song Y., Xiang F. Metaanalysis: contrast-enhanced ultrasound versus conventional ultrasound for differentiation of benign and malignant breast. Ultrasound Med. Biol. 2018; 44 (5): 919-929. https://doi.org/10.1016/j.ultrasmedbio.2018.01.022.

6. Sencha A.N., Mogutov M.S., Patrunov Yu.N., Penyaeva E.I., Kashmanova A.V., Sencha E.A. Ultrasound examination with contrast agents. Moscow: Vidar, 2015. 144 p. (In Russian)

7. Zhang Y., Jiang Q., Zhang Y., Chen J., He Z., Gong L. Diagnostic value of contrast-enhanced ultrasound parametric imaging in breast tumors. J. Breast Cancer. 2013; 16 (2): 208-213. https://doi.org/10.4048/jbc.2013.16.2.208

8. Fleischer A.C., Niermann K.J., Donnelly E.F., Yankeelov T.E., Canniff K.M., Hallahan D.E., Rothenberg M.E. Sonographic depiction of microvessel perfusion: principles and potential. J. Ultrasound Med. 2004; 23; 11: 1499-1506.

9. Sardanelli F., Podo F., Santoro F., Manoukian S., Bergonzi S., Trecate G., Vergnaghi D., Federico M., Cortesi L., Corcione S., Morassut S., Di Maggio C., Cilotti A., Martincich L., Calabrese M., Zuiani C., Preda L., Bonanni B., Carbonaro L.A., Contegiacomo A., Panizza P, Di Cesare E., Savarese A., Crecco M., Turchetti D., Tonutti M., Belli P, Maschio A.D.; High Breast Cancer Risk Italian 1 (HIBCRIT-1) Study. Multicenter Surveillance of Women at High Genetic Breast Cancer Risk Using Mammography, Ultrasonography, and Contrast-Enhanced Magnetic Resonance Imaging. Invest. Radiol. 2011; 46 (2): 94-105. https://doi.org/10.1097/RLI.0b013e3181f3fcdf

10. Rizzatto G., Chersevani R. Role of contrast ultrasound in breast lesions and sentinel lymph nodes. Eur. Radiol. 2005; 4 (6): 225-235.

11. Liu H., Jiang Y.X., Liu J.B., Zhu Q.L., Sun Q., Chang X.Y Contrast-enhanced breast ultrasonography. J. Ultrasound Med. 2009; 28: 911-920.

12. Sidhu PS., Cantisani V., Dietrich C.F., et al. The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall. Med. 2018; 39: 2: e2-e44. https://doi.org/10.1055/a-0586-1107.

13. Zhang Y., Jiang Q., Zhang Y., Chen J., He Z., Gong L. Diagnostic value of contrast-enhanced ultrasound parametric imaging in breast tumors. J. Breast Cancer. 2013; 16 (2): 208-213. https://doi.org/10.1055/a-0586-1107

14. Schroeder R.J., Bostanjoglo M., Rademaker J., Maeurer J., Felix R. Role of power Doppler techniques and ultrasound contrast-enhancement in the differential diagnosis of focal breast lesions. Eur. Radiol. 2003; 13: 68-79. https://doi.org/10.1007/s00330-002-1413-3.

15. Sencha E.A. Contrast-enhanced ultrasound in thyroid nodules diagnosis. Russian Electronic Journal of Radiology(REJR). 2017; 7 (3): 44-52. (In Russian)

16. Mnihovich M.V., Ternov M.M., Extracellular matrix, angiogenesis and cellular environment at the dishormonal hyperplasias, fibroadenomas and breast cancer (light and electron microscopic examination). I.P. Pavlov Russian Medical Biological Herald. 2010; 1; 30-37. (In Russian)

17. Imaging of Male Breast Cancer. A.N. Sencha (eds.). Heidelberg: Springer, 2015. 146 p.

18. Furman-Haran E., Schechtman E., Kelcz F., Kirshen-baum K., Degani H. Magnetic resonance imaging reveals functional diversity of the vasculature in benign and malignant breast lesions. Cancer. 2005; 104 (4): 709-718. https://doi.org/10.1002/cncr.21225.


Review

For citations:


Bikeev Yu.V., Sencha A.N., Radionov V.V., Shubin L.B., Sencha E.A. Qualitative analysis of contrast-enhanced ultrasound in differential diagnosis of breast lesions. Medical Visualization. 2019;(1):87-96. (In Russ.) https://doi.org/10.24835/1607-0763-2019-1-87-96

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ISSN 1607-0763 (Print)
ISSN 2408-9516 (Online)