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Ultrasound diagnosis of endometritis: hemodynamic features of the uterus

https://doi.org/10.24835/1607-0763-2018-6-82-96

Abstract

Objective. To determine the characteristics of hemodynamics of the uterus with endometritis.

Material and methods. A retrospective analysis of 420 patients of reproductive age (19–53 years old) diagnosed with endometritis. The comparison group consisted of 323 women aged 17–52 without gynecological pathology.

Blood flow indicators in the uterine arteries, such as maximum systolic, end-diastolic, and average blood flow velocity (Vmax, Vmin, Vmean), were estimated, and an arterial perfusion index (API) was calculated. With 3D reconstruction of the uterus in angioregime, a vascularization index (VI), a flow index (FI) and a vascular flow index (VFI) of the uterus and endometrium were obtained.

Result. An increase in Vmax, Vmin, Vmean, as well as VI, VFI of the uterus and VI, FI and VFI of the endometrium in the early and middle proliferative phase of the cycle. API had monotonous values, but it should be taken into account in conjunction with VI.

Conclusions. Echography combined with color mapping, spectral Doppler graphics and vascularization index determination using 3D in angio mode is a highly effective method for the diagnosis of endometritis. Characteristic changes in hemodynamics in endometritis manifest as a violation of the venous outflow in the uterus and, especially, in the endometrium, in the presence of hypervascu larization according to data VI in the aggregate of regulatory or reduced indicators of API.

About the Authors

I. A. Ozerskaya
Peoples’ Friendship University of Russia, (RUDN University)
Russian Federation

Irina A. Ozerskaya – doct. of med. sci., Professor, Ultrasound Diagnostics and Surgery Division

Miklukho-Maklay str., 21, bldg. 3, Moscow, 117198. People's Friendship University, Department of ultrasound diagnostics and surgery. Phone: +7-926-606-09-05



A. A. Semiletova
LLC Asklepion Medical Center
Russian Federation
Anastasiya A. Semiletova – gynecologist


G. G. Kazaryan
LLC Scientific and Practical Center for Minimally Invasive Surgery and Gynecology
Russian Federation
Gayane G. Kazaryan – ultrasound diagnostician


References

1. Petrov Yu.A. Chronic endometritis in reproductive age: etiology, pathogenesis, diagnosis, treatment and prevention: Dis. ... doct. of med. sci. M., 2012. 268 p. (In Russian)

2. Dolgushina V.F., Nadvikova T.V., Troshina N.A., Letyagina N.P. Clinical characteristics of chronic endometritis. Ural Medical Journal. 2014; 1 (115): 56–59. (In Russian)

3. Shanin V.Yu. Inflammation. Clinical pathophysiology; Ed. Yu.L. Shevchenko. SPb.: Special literature, 1998: 170–197. (In Russian)

4. Kitaya K., Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am. J. Reprod. Immunol. 2011; 66 (5): 410-415. DOI: 10.1111/j.1600-0897.2011.01051.x.

5. Maleva T.A. Modern methods of diagnosis of chronic endometritis (literature review). Int. J. Applied Basic Res. 2016; 4: 566–568. (in Russian)

6. Adamyan L.V., Smolnova T.Yu., Sidorov V.V. Laser Doppler fluometry in studying the state of the microvasculature in gynecological patients. Reproduction Problems. 2006; 1: 21–30. (In Russian)

7. Al-Tahami B.A., Yvonne-Tee G.B., Halim A.S., Ismail A.A., Rasool A.H. Reproducibility of laser Doppler fluximetry and the process of iontophoresis in assessing microvascular endothelial function using low current strength. Meth. Findings Exp. Clin. Pharmacol. 2010; 32 (3): 181–185. DOI: 10.1358/mf.2010.32.3.1423887.

8. Gaidarova A.Kh., Kulchitskaya D.B., Sycheva A.Yu., Alisultanova L.S., Kotenko N.V., Tarasova T.Yu. The dynamics of the functional characteristics of the microvasculature in patients of late reproductive age with chronic endometritis under the influence of contrast massage. Questions of Balneology, Physiotherapy and Medical Physical Culture. 2014; 91 (4): 33–37. (In Russian)

9. Demidov V.N., Gus A.I. Sonography of the pelvic organs in women. Release IV. Pathology of the uterus and endometrium. VMK: A Practical Guide. M.: Publishing house BINOM, 2016. 160 p. (In Russian) 10. Tapilskaya N.I., Karpeev S.A., Kuznetsova I.V. Chronic endometritis – subclinical inflammatory disease of the pelvic organs. Gynecology. 2014; 1: 104–109. (In Russian)

10. Arutyunyan N.A., Zuev V.M., Ishchenko A.I., Bryunin D.V., Khokhlova I.D., Jibladze T.A. Estimation of the effectiveness of immunohistochemical methods in diagnosing the state of the endometrium in women with a uterine infertility form. Clinical Medicine. 2017; 9 (1): 103–108. DOI: 10.17691/stm2017.9.1.13. (In Russian)

11. Kolmyk V.A., Nasyrov R.A., Kutusheva G.F. Clinicoimmunohistochemical aspects of the restoration of the reproductive function of women with chronic endometritis. Journal of Obstetrics and Women's Diseases. 2014; 63 (4): 34–38. (In Russian).

12. Cleveland G.O., Klyucharov I.V., Deamukov R.A., Tsibulkina V.N. Actual questions of the diagnosis of chronic endometritis. Practical Medicine. 2016; 2 (4): 41–46. (In Russian)

13. Munro M.G., Critchley H.O., Broder M.S., Fraser I.S. FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int. J. Gynaecol. Obstet. 2011; 113 (1): 3–13. DOI: 10.1016/j.ijgo.2010.11.011.

14. Raine-Fenning N.J., Nordin N.M., Ramnarine K.V., Campbell B.K., Clewes J.S., Perkins A., Jonson I.R. Evaluation of the effect of machine settings on quantitative three-dimensional power Doppler angiography: an in-vitro flow phantom experiment. Ultrasound Obstet. Gynecol. 2008; 32 (4): 551–559. DOI: 10.1002/uog.6138.

15. Alcázar J.L., Pascual M.A., Ajossa S., de Lorenzo C., Piras A., Hereter L., Juez L., Fabbri P., Graupera B., Guerriero S. Reproducibility of the International Endometrial Analysis Group Color Score for Assigning the Amount of Flow Within the Endometrium Using Stored 3-Dimensional Volume. J. Ultrasound Med. 2017; 36 (7); 1347–1354. DOI: 10.7863/ultra.16.06002.

16. Mercé L.T., Alcázar J.L., Engels V., Troyano J., Bau S., Bajo J.M. Endometrial volume and vascularity measurement by transvaginal three-dimensional ultrasonography and power Doppler angiography in stimulated and tumoral endometria: intraobserver reproducibility. Gynecol. Oncol. 2006; 100 (3): 544–550. DOI: 10.1016/j.ygyno.2005.09.024

17. Schulten-Wijman M.J., Struijk P.C., Brezinka C., De Jong N., Steegers E.A. Evaluation of volume vascularization index and flow index: a phantom study. Ultrasound Obstet. Gynecol. 2008; 32 (4): 560–564. DOI: 10.1002/uog.6112.

18. Alcázar J.L., Kudla M.J. Three-dimensional vascular indices calculated using conventional power Doppler and high-definition flow imaging: are there differences? J. Ultrasound Med. 2010; 29 (5): 761–766.

19. Bulanov M.N. Ultrasound gynecologists: a course of lectures: in two parts. Part 1, Ch. 1-13. 4th ed. M.: Vidar-M Publishing House, 2017. 560 p. (In Russian)

20. Smetnik V.P., Tumilovich L.G. Non-operative gynecology. Ed. 3. M.: MIA, 2003. 560 p. (In Russian) 22. Kurjak A., Shalan H., Sosic A., Benic S., Zudenigo D., Kupesic S., Predanic M. Endometrial carcinoma in postmenopausal women: evaluation by transvagynal color Doppler ultrasonography. Am. J. Obstet. Gynecol. 1993; 169: 1597–1603.

21. Fedorova E.V., Lipman A.D. The use of color Doppler mapping and Doppler in gynecology. M.: Vidar-M Publishing House, 2002. 104 p. (In Russian)

22. Ozerskaya I.A. Echography in gynecology. Ed. 2, add. M.: Vidar-M Publishing House, 2013. 568 p. (In Russian)

23. Color Doppler in Obstetrics, Gynecology and Infertiliti; Ed. A. Kurjak, S. Kupesic. Zagreb-Seoul: Art Studio Azinovic-Medison, 1999. 135 p.

24. Transvaginal color doppler: infertility, assisted reproduction, obstetrics; Ed. A. Kuryak, A. Mikhailov, S. Kupešić. SPb.: Petropolis Publishers, 2001. 294 p. (In Russian)

25. Gzgzyan A.M., Niauri D.A., Kogan I.Yu., Dzhemlikhanova L.Kh., Krikheli I.O., Fedorova I.D., Lesik E.A., Sharfi Yu.N., Shilnikova E.M. Doppler measurements of uterine vessels in the assessment of endometrial implantation ability during in vitro fertilization programs (IVF). Journal of Obstetrics and Women's Diseases. 2013; 62 (4): 29–34. (In Russian)

26. Kagramanova Z.A., Malinovskaya V.V., Vyzhlova E.V., Lanschakova P.E. New directions in the diagnosis and treatment of endometritis. Immunology, Allergology, Infectology. 2016; 1: 64–67. (In Russian)

27. Strizhakov A.N., Davydov A.I., Musaev Z.M. Dopplerography in obstetrics and gynecology / Ultrasound Doppler diagnostics of vascular diseases Eds Yu.M. Nikitin, A.I. Trukhanov. M.: Vidar, 1998: 330–354. (In Russian)

28. Lysyak D.S., Novolodskaya O.A., Bystritskaya T.S. Uterine hemodynamics in women of reproductive age with a normal menstrual cycle. Amur Medical Journal. 2014; 2 (6): 84–87. (In Russian)

29. Plyasunova M.P., Khlybova S.V., Chicherina E.N. Comparative evaluation of ultrasound and Doppler parameters in chronic endometritis. Ultrasound and Functional Diagnostics. 2014; 2: 57–64. (In Russian) 32. Ozerskaya I.A., Semiletova A.A., Kazaryan G.G. Ultrasound diagnosis of endometritis (B-mode). Ultrasound and Functional Diagnostics. 2017; 6: 36–52. (in Russian)


Review

For citations:


Ozerskaya I.A., Semiletova A.A., Kazaryan G.G. Ultrasound diagnosis of endometritis: hemodynamic features of the uterus. Medical Visualization. 2018;22(6):82-96. (In Russ.) https://doi.org/10.24835/1607-0763-2018-6-82-96

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