EVALUATION OF LIPID CONTENT IN PATIENTS WITH LIVER STEATOSIS AND STEATOHEPATITIS USING PROTON MR-SPECTROSCOPY
https://doi.org/10.24835/1607-0763-2018-4-50-58
Abstract
Aim. Evaluation of proton MR spectroscopy in the diagnostics of non-alcoholic fatty liver disease.
Materials and methods. 70 patients (40 men, 30 women) with non-alcoholic fatty liver disease were included in the study. Average age of patients was 42 ± 11 years. All patients were divided in two groups. The first group included patients with liver steаthosis (n = 37). Patients with steatohepatitis detected by clinical data formed the second group (n = 33). All patients underwent MR spectroscopy for liver fat content evaluation in two time points (prescreening and after 6 months treatment).
Results. MR spectroscopy showed fat content in patients with liver steatosis in the range from 7.5% to 58.4%, the median was 22.4% (lower and upper quartiles were 14.9% and 28.7%). After 6 months the liver fat content significantly decreased up to 1.5–43.7%, the median was 13.5% (the lower and upper quartiles were 5.54% and 18.9%). In patients with steatohepatitis the fat content calculated by MR spectroscopy ranged from 10.5% to 60%, the median was 28.8% (the lower and upper quartiles were 16.5% and 31.2%). There was no significant difference in fat content in this group after 6 months therapy (the median was 26.7%, the lower and upper quartiles were 14.2% and 28.7%, p = 0.22).
Conclusion. Proton MR spectroscopy can be successfully used in patients with non-alcoholic fatty liver disease for liver fat content quantification in steatosis and steatohepatitis. MR spectroscopy can be discussed as a non-invasive biopsy alternative for dynamic evaluation during treatment.
About the Authors
S. K. Ternovoy
National Medical Research Center of Сardiology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation.
Russian Federation
Russian Federation
Sergey K. Ternovoy – academician of the RAS, doct. of med. sci., Professor, Head of the tomography department; Head of the Department of Imaging and Radiation Therapy.
Moscow.G. A. Shiryaev
National Medical Research Center of Сardiology.
Russian Federation
Russian Federation
Grigory A. Shiryaev – Radiologist.
Moscow.
D. V. Ustyuzhanin
National Medical Research Center of Сardiology.
Russian Federation
Russian Federation
Dmitry V. Ustyuzhanin – cand. of med. sci., Senior Researcher.
Moscow.
D. T. Abdurakhmanov
Clinic of Nephrology, Internal and Occupational Diseases named after E.M. Tareev.
Russian Federation
Russian Federation
Jamal T. Abdurakhmanov – doct. of med. sci., associate professor.
Moscow.
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Review
For citations:
Ternovoy S.K., Shiryaev G.A., Ustyuzhanin D.V., Abdurakhmanov D.T. EVALUATION OF LIPID CONTENT IN PATIENTS WITH LIVER STEATOSIS AND STEATOHEPATITIS USING PROTON MR-SPECTROSCOPY. Medical Visualization. 2018;(4):50-58. (In Russ.) https://doi.org/10.24835/1607-0763-2018-4-50-58
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