Neuroimaging signs of brain lesions in patients with gene-associated microangiopathy (CADASIL)
https://doi.org/10.24835/1607-0763-2018-3-17-25
Abstract
Purpose. To evaluate specific changes in MRI of the human brain, associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Materials and methods. We enrolled 24 patients with genetically confirmed CADASIL (19–81 y.o.). The following MRI sequences were performed for every subject: T1 MPR, T2, T2-FLAIR, DTI and SWI. Brain tissue lesions were assessed using STandards for ReportIng Vascular changes on nEuroimaging (STRIVE).
Results. In the CADASIL group the following changes were observed (in % of patients): recent small subcortical infarcts – none; lacunes – 54%; white matter hyperintensities (WMH) by Fazekas 1 – 12%, Fazekas 2 – 17%, Fazekas 3 – 71% (sites of predilection: anterior temporal lobe and external capsule); cerebral microbleeds – 42%; enlarged perivascular spaces – 88%; brain atrophy – 27%.
Conclusion. Neuroimaging signs of brain lesions are common for all types of cerebral small vessel disease, including CADASIL. However, there are some features in patients with CADASIL. The detection of petechial intraparenchymal hemorrhages is a diagnostically and prognostically useful marker, so it is very important to use gradient echo planar T2* or SWI sequence in the conventional MRI protocol.
About the Authors
N. S. Kurochkina
Research Center of Neurology
Russian Federation
Russian Federation
Nadezhda S. Kurochkina – postgraduate student
125367 Moscow, Russia, Volokolamskoe sh., 80
A. A. Moroz
Research Center of Neurology
Russian Federation
Russian Federation
Anna A. Moroz – postgraduate student
Moscow
R. N. Konovalov
Research Center of Neurology
Russian Federation
Russian Federation
Rodion N. Konovalov – cand. of med. sci., Senior Researcher
Moscow
N. Yu. Abramycheva
Research Center of Neurology
Russian Federation
Russian Federation
Natalya Y. Abramycheva – cand. of biol. sci., Senior Researcher
Moscow
М. V. Krotenkova
Research Center of Neurology
Russian Federation
Russian Federation
Marina V. Krotenkova – doct. of med. sci., Head of the Department of Radiology
Moscow
S. N. Illarioshkin
Research Center of Neurology
Russian Federation
Russian Federation
Sergey N. Illarioshkin – corresponding Member of RAS, doct. of med. sci., Professor, Scientific Coordinator of the Department of Neurodegenerative and Hereditary Diseases
Moscow
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Review
For citations:
Kurochkina N.S., Moroz A.A., Konovalov R.N., Abramycheva N.Yu., Krotenkova М.V., Illarioshkin S.N. Neuroimaging signs of brain lesions in patients with gene-associated microangiopathy (CADASIL). Medical Visualization. 2018;(3):17-25. (In Russ.) https://doi.org/10.24835/1607-0763-2018-3-17-25
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