Nonionic Low-Osmolar Monomeric Iodinated Contrast Material: Some Aspects of use for Computed Tomography in Children
https://doi.org/10.24835/1607-0763-2017-6-118-129
Abstract
Iodine containing contrast media are used much frequently now-a-days for computed tomography examinations in children. The group of non-ionic monomers occupies a special place among modern contrast agents. Low osmolarity and viscosity, electrical neutrality and the highest iodine content of these contrast materials provide the best diagnostic efficacy with minimum risk of adverse reactions. However, characteristic anatomic and physiological aspects of a growing child’s body require additional attention and care during diagnostic procedures with use of such contrast agents. This article presents concise literature review of recent years highlighting practical aspects of nonionic lowosmolar iodinated contrast material use for computed tomography assisted diagnostic examinations in child population.
About the Authors
I. A. KondrashovRussian Federation
Igor A. Kondrashov – cand. of med. sci., chief of the department of Diagnostic Imaging of N.F. Filatov CCCH№ 5; assistant professor at the department of Diagnostic Imaging I.I. Mechnikov NWSMU.
192289 Saint-Petersburg, Bukharestskaya str., 134, Phone +7-812-778-84-44
V. Mandal
Russian Federation
V. Mandal – cand. of med. sci., radiologist at the department of Diagnostic Imaging of N.F. Filatov Children City Clinical Hospital № 5
Saint-PetersburgReferences
1. Shimanovsky N.L. Kontrastniye Sredstva: Rukovodstvo po Ratsionalnomu Primeneniyu (Contrast Materials: Guideline for rational use). M.: GEOTAR-Media. 2012. 464 p. (In Russian)
2. Roh S., Laroia A., Practicing safe use of nonionic, lowosmolarity iodinated contrast. Appl. Radiol. 2015; 44 (7): 16–19.
3. ESUR Contrast media Guideline version 9.0, 2016 [Electronic source] URL: http://www.esur.org/esurguidelines/ (reviewed on 26.10.2017).
4. ACR manual on contrast media, version 10.3. American College of Radiology. 2017: 50-57. [Electronic source] URL: http://www.acr.org/quality-safety/resources/contrastmanual (reviewed on 27.10.2017).
5. Kartashova O.M., Gek E.V., Kartashov M.V. Computed Tomography with Bolus Contrast Enhancement in Childhood. Medical Visualization. 2010; 5: 132–139. (In Russian)
6. Callahan M.J., Servaes S., Lee E.Y., Towbin A.J., Westra S.J., Frush D.P. Practice Patterns for the Use of Iodinated IV Contrast Media for Pediatric CT Studies: A Survey of the Society for Pediatric Radiology. Am. J. Roentgenol. 2014; 202: 872–879. DOI: 10.2214/AJR.13.11106.
7. Polyaev Yu.A., Shimanovsky N.L. Safety of the currently available iodinated contrast agents. Vestnik Rentgenologii i Radiologii. 2010; 4: 48–56. (In Russian).
8. Shimanovsky N.L., NapolovYu.K., Korobkova I.Z. On the possible development of anaphylactic/anaphylactoid reactions from the use of iodinated radiopaque agents. Vestnik Rentgenologii i Radiologii. 2012; 5: 52–59. (In Russian)
9. Anikin A.V., Kuznetsova G.V., Stepanchenko A.P. Safety Aspects of Using Contrast-Diagnostic Agents for Children. Voprosy Diagnostiki v Pediatrii. 2009; 1: 62–65. (In Russian)
10. Seong J.M., Choi N. K., Lee J., Chang Y., Kim Y.J., Yang B.R., Jin X.M, Kim J.Y., Park B.J. Comparison of the Safety of Seven Iodinated Contrast Media. J. Korean Med. Sci. 2013; 28 (12): 1703–1710. DOI: 10.3346/jkms.2013.28.12.1703.
11. George M., Shannon M. Intravenous contrast agents and associated changes in serum osmolality. Pediatr. Emerg. Care. 2009; 25 (9): 555–557. DOI: 10.1097/PEC.0b013e3181b5b8ce.
12. Davenport M.S., Wang C.L., Bashir M.R., Neville A.M., Paulson E.K. Rate of contrast material extravasations and allergic like reactions: effect of extrinsic warming of lowosmolality iodinated CT contrast material to 37 degrees C. Radiology. 2012; 262: 475–484. DOI: 10.1148/radiol.11111282.
13. Dillman J.R. Update on Contrast Material Use in Children. 2013 [Electronic source] URL: http://www.pedrad.org/portals/5/events/2013/dillmancontrast.pdf(reviewed on 31.10.2017).
14. Callahan M.J., Zurakowski D., Taylor G.A. Nonionic iodinated intravenous contrast material-related reactions: incidence in large urban children’s hospital-retrospective analysis of data in 12,494 patients. Radiology. 2009; 250 (3): 674–681. DOI: 10.1148/radiol.2503071577.
15. Bae K.T., Shah A.J., Shang S.S., Chang J.H., Kanematsu M., Hildebolt C.F. Aortic and hepatic contrast enhancement with abdominal 64-MDCT in pediatric patients: effect of body weight and iodine dose. Am. J. Roentgenol. 2008; 191: 1589–1594. DOI: 10.2214/AJR.07.3576.
16. Rigsby C.K., Gasber E., Seshadri R., Sullivan C., Wyers M., Ben-Ami T. Safety and efficacy of pressure-limited power injection of iodinated contrast medium through central lines in children. Am. J. Roentgenol. 2007; 188: 726–732. DOI: 10.2214/AJR.06.0104.
17. Donnelly L.F., Dickerson J., Racadio J.M. Is hand injection of central venous catheters for contrast enhanced CT safe in children? Am. J. Roentgenol. 2007; 189: 1530–1532. DOI: 10.2214/AJR.07.2274.
18. Cohen M.D. Safe use of imaging contrast agents in children. J. Am. Coll. Radiol. 2009; 6 (8): 576–581. DOI: 10.1016/j.jacr.2009.04.003.
19. Brasch R.C. Contrast media toxicity in children. Pediatr. Radiol. 2008; 38 (Suppl. 2): S281–S284. DOI: 10.1007/s00247-008-0773-5.
20. Sorantin E., Weissensteiner S., Hasenburger G., Riccabona M. CT in children – dose protection and general considerations when planning a CT in a child. Eur. J. Radiol. 2013; 82 (7): 1043–1049. DOI: 10.1016/j.ejrad.2011.11.041.
21. Karcaaltincaba M., Oguz B., Haliloglu M. Current status of contrast-induced nephropathy and nephrogenic systemic fibrosis in children. Pediatr. Radiol. 2009; 39 (3): 382–S384. DOI: 10.1007/s00247-009-1236-3.
22. Zo’o M., Hoermann M., Balassy C. Renal safety in pediatric imaging: randomized, double-blind phase IV clinical trial of iobitridol 300 versus iodixanol 270 in multidetector CT. Pediatr. Radiol. 2011; 41: 1393–1400. DOI: 10.1007/2Fs00247-011-2164-6.
23. Mruk B. Renal Safety of Iodinated Contrast Media Depending on Their Osmolarity – Current Outlooks. Pol. J. Radiol. 2016. 81:157–165. DOI 10.12659/2FPJR.895406.
24. Zelenov M.A. Risk assessment and prevention of contrastinduced nephropathy in radiocontrast-enhanced examinations. Diagnosticheskaya I interventsionnaya radiologiya. 2007; 1 (2): 80–84. (In Russian)
25. Vorobyeva L.E., Kusstova O.V. Methodology of multi-slice computer tomography and its capability in diagnosing anomalies of kidneys and ureters in children. Voprosy diagnostiki v pediatrii. 2009; 1 (5): 20–25. (In Russian)
26. Tsygina E.N., Dvoryakovsky I.V., Tsygin A.N. Imaging Kidneys and Urinary Tract in Pediatrics. Medical Visualization. 2009; 2: 123–130. (In Russian)
27. Davenport M.S., Dillman J.R., Cohan R.H. Contrast material-induced nephrotoxicity and intravenous lowosmolality iodinated contrast material. Radiology. 2013; 267 (1): 94–105. DOI: 10.1148/radiol.12121394.
28. Shimanovskii N.L. Safety of current iodine roentgen contrast media with a glance of update guidelines of international experts and clinicians associations. Russian Electronic Journal of Radiology. 2012; 2 (1): 12–19. (In Russian)
29. Schwartz G.J., Muñoz A., Schneider M.F., Mak R.H., Kaskel F., Warady B.A., Furth S.L. New equations to estimate GFR in children with CKD. J. Am. Soc. Nephrol. 2009; 20 (3): 629–637. DOI: 10.1681/ASN.2008030287.
30. Delanghe J.R. How to estimate GFR in children. Nephrol. Dial. Transplant. 2009; 24 (3): 714–716. DOI: 10.1681/ASN.2008030287.
31. Tsygina E.N., Kucherenko A.G., Zadkova G.F., Smirnov I.E., Kupriyanova O.O., Sorokina T.E., Lukina O.F., Bakanov M.I., Kurlova A.V., Tsygin A.N. Impact of Contrast Media on Renal Function and Homeostasis in Children with Nephropathies. Medical Visualization. 2010; 2: 109–114. (In Russian)
32. Gomi T., Nagamoto M., Hasegawa M., Katoh A., Sugiyama M., Murata N., Kunihiro T., Kohda E. Are there any differences in acute adverse reactions among five low-osmolar non-ionic iodinated contrast media? Eur. Radiol. 2010; 20 (7): 1631–1635. DOI: 10.1007/s00330-009-1698-6.
33. Rose T.A. Jr., Choi J.W. Intravenous Imaging Contrast Media Complications: The Basics That Every Clinician Needs to Know. Am. J. Med. 2015; 128 (9): 943–949. DOI: 10.1016/j.amjmed.2015.02.018.
34. Smirnov I.E., Tsygina E.N., Kucherenko A.G., Zadkova G.F., Lukina O.F., Kupriyanova O.O., Sorokina T.E., Bakanov M.I., Zorkin S.N., Yatsyk S.P., Tsygin A.N., Studies of safety and functional and metabolic effects of non-ionic contrast media in children with nephropathies. Pediatricheskaya Farmakologiya. 2010; 7 (2): 78–82. (In Russian)
35. Zaharkina E.V. The influence of x-ray contrast preparations on kidney function in children suffering from pyelonephritis. Pediatriya. 2008; 87 (3): 27–31. (In Russian)
36. Marana I. Current view of the prevention of contrastinduced nephropathy. Vestnik Rentgenologii i Radiologii. 2012; 2: 61–65. (In Russian)
37. Mironova O.Yu. Contrast Media Induced Nephropathy. Terapevticheskyi Arkhiv. 2013; 6: 90–95. (In Russian)
38. Fominyh V.P., Fineshin I.N., Sharikov P.V. Roentgen Contrast Media. View of Resuscitator. Russian Electronic Journal of Radiology. 2012; 2 (1): 35–43. (In Russian)
39. Trout A.T., Dillman J.R., Ellis J.H., Cohan R.H., Strouse P.J. Patterns of intravenous contrast material use and corticosteroid premedication in children – a survey of Society of Chairs of Radiology in Children’s Hospitals (SCORCH) member institutions. Pediatr. Radiol. 2011; 41 (10): 1272–1283. DOI: 10.1007/s00247-011-2112-5.
40. Kotlyarov P.M., Burnashkina S.P., Shimanovski N.L. Multispiral Computer Tomographies with Ultravist Bolus Enhancement in Pediatric Urology. Luchevaya Diagnostika i Terapiya. 2013; 4(4): 101–109. (In Russian)
41. Petryajkin А.V., Razumovskiy А.Yu., Ublinskij M.V., SidenkoА.V., Guryakov S.Yu., Gorokhov D.V. Multislice computed tomography with contrast enhancement in the diagnosis of surgical diseases of the thoracic cavity in children. Detskaya Khirurgiya. 2013; 4: 9–15. (In Russian)
42. Andreucci M., Solomon R., Tasanarong A. Side Effects of Radiographic Contrast Media: Pathogenesis, Risk Factors, and Prevention. BioMed Research International. 2014. [Electronic source] URL: http://www.hindawi.com/journals/bmri/2014/741018/(reviewed on 31.10.2017).
43. Rhee C.M., Bhan I., Alexander E.K., Brunelli E.K. Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. Arch. Internal Med. 2012; 172 (2): 153–159. DOI 10.1001/archinternmed.2011.677.
44. Barr M.L., Chiu H.K., Li N, Yeh M.W, Rhee C.M., Casillas J., Iskander P.J., Leung A.M. Thyroid Dysfunction in Children MEDICAL VISUALIZATION 2017, V. 21 , N6 129 Exposed to Iodinated Contrast Media. J Clin. Endocrinol. Metab. 2016; 101 (6): 2366–2370. DOI: 10.1210/jc.2016-1330.
45. Alihanov A.A., Guschin I.S., Shimanovsky N.L. Clinical Experience and Pharmacological Evidences of Iopromide (Ultravist) Safety Application. Medical Visualization. 2013; 1: 122–129. (In Russian).
46. Karmazanovsky G.G. “The old” Nonionic X-ray Contrast Media Ioversol – “the new player” in the Russian market of Contrast Media. Medical Visualization. 2007; 2: 135–139. (In Russian)
47. Karmazanovsky G.G. Contrast Agents for MDCT Today: Ioversol – Ways to Optimize the Use and Maximize Contrast Enhancement. Medical Visualization. 2014; 6: 108–118. (In Russian)
48. Ivakhnenko O.I., Khachtaryan G.R., Avxentyeva M.V., Rebrova O.Yu., Muller-York A. Pharmacoeconomic analysis of Ioversol for Cont Exposed to Iodinated Contrast Media. J Clin. Endocrinol. Metab. 2016; 101 (6): 2366–2370. DOI: 10.1210/jc.2016-1330.
49. Kondrashov I.A., Mandal V., Razygraeva E.A., Khamchenko T.A. Features of CT-enterography in assessing the prevalence and severity of inflammatory bowel disease in children. Nevskyi Radiologichesky Forum – Sbornik nauchnikh rabot (Nevsky Radiological Forum – Collection of scientific works); Ed. V.E. Savello. SPB.: ELBI-SPB., 2015: 338–340. (In Russian)
50. Kondrashov I.A., Mandal V., Kondrashov I.I., Razygraeva E.A., Khamchenko T.A. Rational approach towards neuroimaging of childhood stroke cases at general emergency hospital. Nevskyi Radiologichesky Forum – Sbornik nauchnikh rabot (Nevsky Radiological Forum – Collection of scientific works); Ed. V.E. Savello. SPB.: ELBI-SPB, 2015: 340–342. (In Russian)
Review
For citations:
Kondrashov I.A., Mandal V. Nonionic Low-Osmolar Monomeric Iodinated Contrast Material: Some Aspects of use for Computed Tomography in Children. Medical Visualization. 2017;(6):118-129. (In Russ.) https://doi.org/10.24835/1607-0763-2017-6-118-129