Eighth Edition of the International TNM Classification of Malignant Tumors of the Liver
https://doi.org/10.24835/1607-0763-2017-6-41-48
Abstract
New criteria for T, N and M categories and characteristics of the stages of hepatocellular carcinoma and intrahepatic cholangiocarcinoma are presented in the eighth edition of the international TNM classification of malignant tumors in 2017. The differences of this classification from the previous seventh edition of 2009 are noted, due to the receipt of new data on the survival of patients. The main characteristics of the primary tumor remained its size, the number of nodes and the presence of vascular invasion.
About the Authors
A. I. Shchegolev
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
Aleksandr I. Shchegolev – doct. of med. sci., professor, Head of Department of Morbid Anatomy.
Academika Oparina str., 4, Moscow, 117997, Phone: 8-495-531-44-44
U. N. Tumanova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
Ulyana N. Tumanova – scientific researcher, Department of Morbid Anatomy of Research Center.
MoscowG. G. Karmazanovsky
A.V. Vishnevsky Institute of surgery
Russian Federation
Russian Federation
Grigory G. Karmazanovsky – corresponding member of RAS, doct. of med. sci., professor, Head of the Radiology Department.
MoscowReferences
1. Denoix P.F. Nomenclature des cancer. Bull. Inst. Nat. Hyg. (Paris). 1944: 69–73.
2. International Union Against Cancer (UICC) Committee on Clinical Stage Classification and Applied Statistics. Clinical Stage Classification and Presentation of Results, Malignant Tumours of the Breast and Larynx. Paris, 1958.
3. TNM classification of malignant tumours. Eds J.D. Brierley, M.K. Gospodarowicz, Ch. Wittekind. 8th ed New York: Wiley-Blackwell, 2017. 272 p.
4. AJCC cancer staging manual, Eighth ed. Ed. Chief M.B. Amin. Springer, 2017. 1024 p.
5. TNM Classification of malignant tumours. 7th ed. Eds L.H. Sobin, M.K. Gospodarowicz, Ch. Wittekind. New York: Wiley-Blackwell, 2009. 310 p.
6. Bosman F.T., Carneiro F., Hruban R.H., Theise N.D. eds. World Health Organization Classification of Tumours of the Digestive System. Lyon: IARC. 2010. 417 p.
7. Shchegolev A. I., Mishnev O. D. Oncomorphology liver. M.: Publishing RSSU, 2006; 252 p. (In Russian)
8. Torbenson M. Fibrolamellar carcinoma: 2012 update. Scientifica (Cairo). 2012; 2012: 743790. DOI: 10.6064/2012/743790.
9. Mayo S.C., Mavros M.N., Nathan H., Cosgrove D., Herman J.M., Kamel I., Anders R.A., Pawlik T.M. Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective. J. Am. Coll. Surg. 2014; 218: 196–205. DOI: 10.1016/j.jamcollsurg.2013.10.011.
10. Jernigan P.L., Wima K., Hanseman D.J., Hoehn R.S., Ahmad S.A., Shah S.A., Abbott D.E. Natural history and treatment trends in hepatocellular carcinoma subtypes: Insights from a national cancer registry. J. Surg. Oncol. 2015; 112: 872–876. DOI: 10.1002/jso.24083.
11. Edmondson H.A., Steiner P.E. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954; 7: 462–504.
12. Kudo M., Chung H., Haji S., Osaki Y., Oka H., Seki T., Kasugai H., Sasaki Y., Matsunaga T. Validation of a new prognostic staging system for hepato-cellular carcinoma: the JIS score compared with the CLIP score. Hepatology. 2004; 40: 1396–1405. DOI: 10.1002/hep.20486.
13. Toyoda H., Kumada T., Kiriyama S., Sone Y., Tanikawa M., Hisanaga Y., Yamaguchi A., Isogai M., Kaneoka Y., Washizu J. Comparison of the usefulness of three staging systems for hepatocellular carcinoma (CLIP, BCLC, and JIS) in Japan. Am. J. Gastroenterol. 2005; 100: 1764–1771. DOI: 10.1111/j.1572-0241.2005.41943.x.
14. Tumanova U.N., Shchegolev A.I. Staging systems of hepatocellular carcinoma. Eksperimental'naya i klinicheskaya gastrojenterologiya. 2016; 7: 121–128. (In Russian)
15. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group. Hepatology. 1994: 20: 15–20.
16. Batts K.P., Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am. J. Surg. Pathol. 1995; 19: 1409–1417.
17. Ishak K., Baptista A., Bianchi L., Callea F., De Groote J., Gudat F., Denk H., Desmet V., Korb G., MacSween R.N. Histological grading and staging of chronic hepatitis. J. Hepatol. 1995; 22: 696–699.
18. Vauthey J.N., Lauwers G.Y., Esnaola N.F., Do K.A., Belghiti J., Mirza N., Curley S.A., Ellis L.M., Regimbeau J.M., Rashid A., Cleary K.R., Nagorney D.M. Simplified staging for hepatocellular carcinoma. J. Clin. Oncol. 2002; 20: 1527–1536. DOI: 10.1200/JCO.2002.20.6.1527.
19. Shindoh J., Andreou A., Aloia T.A., Zimmitti G., Lauwers G.Y., Laurent A., Nagorney D.M., Belghiti J., Cherqui D., Poon R.T., Kokudo N., Vauthey J.N. Microvascular invasion does not pre-dict long-term survival in hepatocellular carcinoma up to 2 cm: reappraisal of the staging system for solitary tumors. Ann. Surg. Oncol. 2013; 20: 1223–1229. DOI: 10.1245/s10434-012-2739-y.
20. Chan A.C., Fan S.T., Poon R.T., Cheung T.T., Chok K.S., Chan S.C., Lo C.M. Evaluation of the seventh edition of the American Joint Committee on Cancer tumour-nodemetastasis (TNM) staging system for patients undergoing curative resection of hepatocellular carcinoma: implications for the development of a refined staging system. HPB (Oxford). 2013; 15: 439–448. DOI: 10.1111/j.1477-2574.2012.00617.x.
21. An C., Choi G.H., Lee H.S., Kim M.J. Assessment of preoperative magnetic resonance imaging staging in patients with hepatocellular carcinoma undergoing resection compared with the seventh American Joint Committee on Cancer System. Invest. Radiol. 2012; 47: 634–641. DOI: 10.1097/RLI.0b013e3182630e8d.
22. Shah S., Shukla A., Paunipagar B. Radiological features of hepatocellular carcinoma. J. Clin. Exp. Hepatol. 2014; 4: 63–66. DOI: 10.1016/j.jceh.2014.06.009.
23. Tumanova U.N., Karmazanovsky G.G., Shchegolev A.I. LIRADS system for computer-tomographic diagnosis of hepatocellular carcinoma. Medical Visualization. 2014; 6: 44–50. (In Russian)
24. Krinsky G. Imaging of dysplastic nodules and small hepatocellular carcinomas: experience with explanted livers. Intervirology. 2004; 47: 191–198. DOI: 10.1159/000078472.
25. Lee J.M., Choi B.I. Hepatocellular nodules in liver cirrhosis: MR evaluation. Abdom. Imaging. 2011; 36: 282–289. DOI: 10.1007/s00261-011-9692-2.
26. Tumanova U.N., Karmazanovsky G.G., Shchegolev A.I. Preneoplastic nodular lesions of the liver: morphological and magnetic resonance tomography comparison. Medical Visualization. 2016; 6: 41–51. (In Russian)
27. Tumanova U.N., Karmazanovsky G.G., Shchegolev A.I. Densitometric characteristics of hepatocellular carcinoma at spiral computed tomography. Medical Visualization. 2012; 6: 42–49. (In Russian)
28. Tumanova U.N., Karmazanovsky G.G., Shchegolev A.I. Characterize the degree of vascularization of hepatocellular carcinoma at spiral computed tomography. Medical Visualization. 2013; 1: 52–58. (In Russian)
29. Trefylov A.A., Karelskaya N.A., Karmazanovsky G.G., Stepanova Yu.A. Radiological diagnosis of hepatocellular carcinoma in patients with liver cirrhosis. Diagnosticheskaya i interventsionnaya radiologiya. 2014; 2-2: 70–80. (In Russian)
30. Andreeva R.M., Samsonov V.A., Fedorova L.A., Nekachalov V.V. Clinical and morphological characteristics of liver cancer. Voprosy onkologii. 1966; 3: 91–92. (In Russian)
31. Ringe K.I., Wacker F. Radiological diagnosis in cholangiocarcinoma: Application of computed tomo graphy, magnetic resonance imaging, and positron emission tomography. Best Pract. Res. Clin. Gastroenterol. 2015; 29: 253–265. DOI: 10.1016/j.bpg.2015.02.004
32. Arrivé L., Hodoul M., Arbache A., Slavikova-Boucher L., Menu Y., El Mouhadi S. Magnetic resonance cholangiography: Current and future perspectives. Clin. Res. Hepatol. Gastroenterol. 2015; 39: 659–664. DOI: 10.1016/j.clinre.2015.07.005.
33. Jang H.J., Yu H., Kim T.K. Contrast-enhanced ultrasound in the detection and characterization of liver tumors. Cancer Imaging. 2009; 9: 96–103. DOI: 10.1102/1470-7330.2009.0015.
34. Lazaridis K.N., Gores G.J. Primary sclerosing cholangitis and cholangiocarcinoma. Semin. Liver Dis. 2006; 26: 42–51. DOI: 10.1055/s-2006-933562.
Review
For citations:
Shchegolev A.I., Tumanova U.N., Karmazanovsky G.G. Eighth Edition of the International TNM Classification of Malignant Tumors of the Liver. Medical Visualization. 2017;(6):41-48. (In Russ.) https://doi.org/10.24835/1607-0763-2017-6-41-48
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