The effect of changes in tumor volume and the level of FDG absorption on the duration of progression-free survival in patients with lymphomas
https://doi.org/10.24835/1607-0763-1551
Abstract
The article presents the results of an assessment of the relationship between metabolic parameters – tumor volume and the level of fluorodeoxyglucose absorption and the duration of progression-free survival in patients with 3 points on the PET scale. The purpose of the work is to find the relationships between the values and the duration of the period of PFS. In the course of the work, the average values of FDG absorption and tumor volume in patients with different periods of PFS were measured and compared. It was revealed that patients with a PFS period of more than 24 months have statistically significant differences in these parameters. These results can be interpreted as an additional factor in the course and prognosis of the disease in patients with lymphomas after treatment and a score of 3 points on the PET scale.
About the Authors
S. A. AlekseevRussian Federation
Sergey A. Alekseev – Cand. of Sci. (Med.), Head of the CT and MRI Department of the X-ray Department of the Radiation Diagnostics Center, Main Military Clinical Hospital named after academician N.N. Burdenko of the Ministry of defense of the Russian Federation, Moscow
https://orcid.org/0000-0003-1329-8689
V. N. Troyan
Russian Federation
Vladimir N.Troyan – Doct. of Sci. (Med.), Professor, Head of the Radiation Diagnostics Center, Main Military Clinical Hospital named after academician N.N. Burdenko of the Ministry of defense of the Russian Federation, Moscow
https://orcid.org/ 0000-0002-8008-9660
O. A. Rukavitsyn
Oleg A. Rukavitsyn – Doct. of Sci. (Med.), Professor, Head of the Hematology Center, Main Military Clinical Hospital named after academician N.N. Burdenko of the Ministry of defense of the Russian Federation, Moscow
https://orcid.org/ 0000-0002-1309-7265
References
1. Atabayeva A.K., Khismetova Z.A., Nurakhmetova Zh.B. Epidemiology of neoplasms of the blood system. Literature review. Nauka i Zdravookhranenie = Science & Healthcare. 2021; 23 (6): 188–197. https://doi.org/10.34689/SH.2021.23.6.020 (In Russian)
2. Galchenko L.I., Demchenkova M.V., Pavlyuk I.A. et al. Positron emission tomography in the diagnosis and evaluation of the effectiveness of the treatment of Hodgkin’s lymphoma. Medicine and High Technology. 2022; 3: 51–57. https://doi.org/10.34219/2306-3645-2022-12-3-51-57 (In Russian)
3. Efremova D.S., Ilyina N.L. Nuclear medicine and its prospects. Science Bulletin. 2023; 5, 4 (61): 437–445. vestnik-nauki.com/article/7972 (In Russian)
4. Radiation diagnostics in diseases of the blood system / Ed. E.V. Kryukov. Moscow: GEOTAR-Media, 2021. 224 p. ISBN 978-5-9704-6333-8. https://doi.org/10.33029/9704-6333-8-DIA-2021-1-224 (In Russian)
5. Bayembaev F., Rakhimzhanova R., Dautov T. et al. PET/CT disadvantages in patients with lymphoma: A literature review. Oncology and Radiology of Kazakhstan. 2023; 1 (67): 62–67. https://doi.org/10.52532/2521-6414-2023-1-67-62-67 (In Russian)
6. Hematology: National guide / Ed. O.A. Rukavitsyn. 2nd ed., revised. and additional. Moscow: GEOTAR-Media, 2024. 916 p. ISBN 978-5-9704-8188-2. https://doi.org/10.33029/9704-8188-2-GEM-2024-1-916 (In Russian)
7. Aslanidis I.P., Metelkina M.V., Mukhortova O.V. et al. Volumetric PET-biomarkers in Hodgkin's lymphoma. The initial experience of automatic and manual methods of evaluation. Russian Electronic Journal of Radiology@. 2022; 12 (1): 80–88. https://doi.org/10.21569/2222-7415-2022-12-1-80-88 (In Russian)
8. Capobianco N., Meignan M., Cottereau A.S. et al. Deep-Learning 18F-FDG Uptake Classification Enables Total Metabolic Tumor Volume Estimation in Diffuse Large B-Cell Lymphoma. J. Nucl. Med. 2021; 62 (1): 30–36. https://doi.org/10.2967/jnumed.120.242412
9. Mangasarova Ya.K., Magomedova A.U., Nesterova E.S. et al. Intermediate positron emission tomography in patients with primary mediastinal large B-cell lymphoma. Russian Journal of Hematology and Transfusiology. 2020; 65 (S1): 175. (In Russian)
10. Manturova N.E., Mel'nikov D.V., Startseva O.I. et al. Large cell breast implant-associated lymphoma – current state of the problem. Plastic Surgery and Aesthetic Medicine. 2020; 1: 69–78.
11. https://doi.org/10.17116/plast.hirurgia202001169 (In Russian)
12. Gallamini A., Zwarthoed C. Interim FDG-PET Imaging in Lymphoma. Semin Nucl Med. 2018; 48 (1): 17–27. https://doi.org/10.1053/j.semnuclmed.2017.09.002
13. Canellos G.P. Residual mass in lymphoma may not be residual disease. J. Clin. Oncol. 1988; 6 (6): 931–933. https://doi.org/10.1200/JCO.1988.6.6.931
14. El-Galaly T.C., Gormsen L.C., Hutchings M. PET/CT for staging; past, present, and future. Semin. Nucl. Med. 2018; 48 (1): 4–16. https://doi.org/10.1053/j.semnuclmed.2017.09.001
15. Juweid M.E. 18F-FDG PET as a Routine Test for Posttherapy Assessment of Hodgkin's Disease and Aggressive Non-Hodgkin's Lymphoma: Where Is the Evidence? J. Nucl. Med. 2008; 49 (1) 9–12. https://doi.org/10.2967/jnumed.107.046292
16. Chen Y.K., Yeh C.L., Tsui C.C. et al. F-18 FDG PET for evaluation of bone marrow involvement in non-hodgkin lymphoma: a meta-analysis. Clin. Nuclear Med. 2011; 36 (7): 553–559. https://doi.org/10.1097/RLU.0b013e318217aeff
17. Kobe C., Dietlein M., Hellwig D. PET/CT for Lymphoma Post-therapy Response Assessment in Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma. Semin. Nucl. Med. 2018; 48 (1): 28–36. https://doi.org/10.1053/j.semnuclmed.2017.09.003
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For citations:
Alekseev S.A., Troyan V.N., Rukavitsyn O.A. The effect of changes in tumor volume and the level of FDG absorption on the duration of progression-free survival in patients with lymphomas. Medical Visualization. https://doi.org/10.24835/1607-0763-1551
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