Difficulties in assessing the local prevalence of pancreatic ductal adenocarcinoma using computed tomography after neoadjuvant chemotherapeutic treatment

Aim: to demonstrate the difficulties of assessing the local prevalence of pancreatic ductal adenocarcinoma using computed tomography (CT) after neoadjuvant chemotherapeutic treatment using the example of a series of clinical observations.

Materials and methods. A search was conducted for scientific publications and clinical recommendations in the PubMed information and analytical system using the keywords “pancreatic ductal adenocarcinoma”, “resectable and borderline resectable”, “locally advanced cancer”, “neoadjuvant therapy response”, “post-chemotherapy computed tomography”, “radiomics” over the past 10 years.

Results. From 30 sources found, 23 were selected for review.

Conclusion. Computed tomography remains the main method of assessing the local prevalence of ductal adenocarcinoma of the pancreas, however, in some cases it does not allow differentiating tumor, fibrous and inflammatory changes after neoadjuvant chemotherapeutic treatment.

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