Non-Invasive Measurement of Oxygen Metabolism. Part 2: New Techniques in PET and MRI
https://doi.org/10.24835/1607-0763-1376
Abstract
Oxygen metabolism is a key factor in the life of a living organism. The article is the second part of a review of methods for measuring oxygen metabolism.
Purpose. The aim of this review is to provide an insight into newly developed perfusion measurement techniques based on MRI and CT comparing their accuracy with the “gold standard” H215O PET measurements and describing their role in today’s clinical practice.
Materials and methods. More than 200 Pubmed publications were analyzed for the keywords “perfusion, MRI, CT, ASL, oxygen metabolism”. Relevant publications that do not contain these keywords or contain them in a different wording were also studied.
Results. This review selected 49 publications describing CT and MR perfusion using contrast agents and MR ASL perfusion. Examples of the use of the described methods in fundamental research and applied medicine are given.
Conclusion. The quantitative results obtained using novel non-invasive molecular imaging techniques are in most cases comparable to H215O PET data, which opens the way for broad use of MRI and CT perfusion and oxygen metabolism measurements in clinical practice.
Supporting agencies: The research was supported by a grant from the Russian Science Foundation (project No. 22-25-00201)
About the Authors
Andrey A. Postnov
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; 16, 4rd Tverskaya-Yamskaya str., Moscow 125047, Russian Federation
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); 115230, Moscow, Kashirskoe shosse, 31, Russian Federation
P.N. Lebedev Physical Institute of the Russian Academy of Sciences; 53, Leninsky prospect, Moscow 119991, Russian Federation
Russian Federation
Russian Federation
Andrey A. Postnov – Cand. of Sci. (Phys.-Math.), researcher of Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia; Assistant Professor of National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); researcher of P.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow
Diana B. Kalaeva
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; 16, 4rd Tverskaya-Yamskaya str., Moscow 125047, Russian Federation
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); 115230, Moscow, Kashirskoe shosse, 31, Russian Federation
Russian Federation
Russian Federation
Diana B. Kalaeva – Medical physicist of the Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia; graduate student of National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow
Anton B. Balakhonov
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; 16, 4rd Tverskaya-Yamskaya str., Moscow 125047, Russian Federation
Russian Federation
Russian Federation
Anton B. Balakhonov – Lead Engineer of the Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia, Moscow
Igor’ N. Pronin
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; 16, 4rd Tverskaya-Yamskaya str., Moscow 125047, Russian Federation
Igor’ N. Pronin – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Head of the Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia, Moscow
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For citations:
Postnov A.A., Kalaeva D.B., Balakhonov A.B., Pronin I.N. Non-Invasive Measurement of Oxygen Metabolism. Part 2: New Techniques in PET and MRI. Medical Visualization. 2024;28(2):145-152. (In Russ.) https://doi.org/10.24835/1607-0763-1376
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