Imaging of vaginal cancer. Consensus of experts
https://doi.org/10.24835/1607-0763-1354
Abstract
The article offers the latest view on possibilities of diagnostic algorithm to identify vaginal cancer (VC), rare tumor of the woman’s reproductive system. The algorithm is described as a consensus of leading expert in imaging diagnostics, as well as oncogynecologysts, investigating diagnostic challenges and vaginal cancer therapies. The article sets forth the principal trends in using imaging methods, their role and possibilities for staging VC, planning and assessing the efficacy of applied therapy, on-going surveillance over patients, who have undergone specialized anti-cancer treatment
About the Authors
V. A. SolodkiyRussian Federation
Vladimir A. Solodkiy – Academician of the Russian Academy of Sciences, Professor, Director
86, Profsoyusnaya str., Moscow 117997
N. V. Nudnov
Russian Federation
Nikolai V. Nudnov – Doct. of Sci. (Med.), Professor, Deputy Director (Science), Chief of the Research Institute of Complex Diagnostics of Diseases and Radiotherapy
phone: +7-985-224-04-68
86, Profsoyusnaya str., Moscow 117997
S. P. Aksenova
Russian Federation
Svetlana P. Aksenova – Cand. of Sci. (Med.), Researcher of Laboratory of Radiological Diagnostics of Diseases (including the Breast) of the Research Department for Comprehensive Diagnostics of Diseases and Radiotherapy
86, Profsoyusnaya str., Moscow 117997
N. A. Rubtsova
Russian Federation
Natalia A. Rubtsova – Doct. of Sci. (Med.), head of the department of radiation diagnostics
3, 2nd Botkinsky proezd, Moscow 125284
V. E. Sinitsyn
Russian Federation
Valentin E. Sinitsyn – Doct. of Sci. (Med.), Professor, Head of Department of Radiation Diagnostics and Therapy of the Faculty of Fundamental Medicine; Medical Research and Education Center of Lomonosov Moscow State University
27-10, Lomonosovsky prospekt, Moscow 119192
T. P. Berezovskaia
Russian Federation
Tatiana P. Berezovskaia – Doct. of Sci. (Med.), Professor, Head of the MRI department
10, Zhukov street, Obninsk 249031, Kaluga region
S. V. Ivashina
Russian Federation
Svetlana V. Ivashina – Cand. of Sci. (Med.), senior researcher at the laboratory for complex diagnosis and treatment of diseases of the genitourinary and reproductive systems in adults and children, research department of surgery, urology, gynecology and invasive technologies in oncology
86, Profsoyusnaya str., Moscow 117997
V. G. Bychenko
Russian Federation
Vladimir G. Bychenko – Cand. of Sci. (Med.), Head of radiation diagnostics department
4, Akademika Oparina street, Moscow 117997
A. V. Mishchenko
Russian Federation
Andrei V. Mishchenko – Doct. of Sci. (Med.), Chief Doctor of the Clinic Russian Medical Academy of Continuous Professional Education; Professor Scientific, Clinical and Educational Center "Radiation diagnostics and nuclear medicine" Faculty of Medicine, Federal State Budgetary Educational Institution of Higher Education, St. Petersburg State University; leading researcher of N.N. Petrov National Medical Research Center of Oncology
68, Leningradskaya str., Pesochny, Saint-Petersburg 197758
2/1 bld. 1, Barrikadnaya str., Moscow 125993
M. M. Khodzhibekova
Russian Federation
Malika M. Khodzhibekova – Doct. of Sci. (Med.), Radiologist of the Radionuclide Diagnostics Department
3, 2nd Botkinsky proezd, Moscow 125284
M. A. Chekalova
Russian Federation
Marina A. Chekalova – Doct. of Sci. (Med.), Professor, doctor of ultrasonic diagnostics of Federal Scientific and Clinical Center for Special Types of Medical Care and Medical Technologies, The Federal Medical Biological Agency (FMBA of Russia); Professor, The Peoples' Friendship University of Russia
30, Volokolamskoye shosse, Moscow 125310
6, Miklukho-Maklay str., Moscow 117198
I. B. Antonova
Russian Federation
Irina B. Antonova – Doct. of Sci. (Med.), Нead of the laboratory at the laboratory for complex diagnosis and treatment of diseases of the genitourinary and reproductive systems in adults and children, research department of surgery, urology, gynecology and invasive technologies in oncology
86, Profsoyusnaya str., Moscow 117997
L. A. Ashrafyan
Russian Federation
Levon A. Ashrafyan – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Deputy Director
4, Akademika Oparina street, Moscow 117997
E. G. Novikova
Russian Federation
Elena G. Novikova – Doct. of Sci. (Med.), Professor, Deputy Head of the Department of Tumors of the Reproductive and Urinary Organs
3, 2nd Botkinsky proezd, Moscow 125284
L. I. Krikunova
Russian Federation
Lyudmila I. Krikunova – Doct. of Sci. (Med.), Professor, Chief scientific officer of the Department of Radiation and Combined Methods of Treatment of Gynecological Diseases with the Group of Restorative and Aesthetic Medicine
10, Zhukov street, Obninsk 249031, Kaluga region
References
1. Adams T.S., Rogers L.J., Cuello M.A. Cancer of the vagina: 2021 update. Int. J. Gynecol. Obstet. 2021; 155 (Suppl. 1): 19– 27. https://doi.org/10.1002/ijgo.13867
2. Sinno A.K., Saraiya M., Thompson T.D. et al. Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population. Obstet. Gynecol. 2014; 123 (4): 817–821. https://doi.org/10.1097/AOG.0000000000000171
3. Solopova A.G., Moskvichyova V.S., Blbulyan T.A. et al. Topical issues of prevention, diagnosis and treatment of vulvar and vaginal cancer. Obstetrics, Gynecology and Reproduction. 2018; 12 (4): 62–70. https://doi.org/10.17749/2313-7347. 2018.12.4.062-070 (In Russian)
4. Guo L., Li C., Hua K. Occult vaginal cancer recurrence after hysterectomy: a case report and literature review. J. Int. Med. Res. 2020; 48 (12): 300060520973901. https://doi.org/10.1177/0300060520973901
5. Donati O.F., Lakhman Y., Sala E. et al. Role of preoperative MR imaging in the evaluation of patients with persistent or recurrent gynaecological malignancies before pelvic exenteration. Eur. Radiol. 2013; 23 (10): 2906–2915. https://doi.org/10.1007/s00330-013-2875-1
6. Kaprin A.D., Starinsky V.V., Shakhzadova A.O. The state of oncological care for the population of Russia in 2021. M.: MNIOI im. P.A. Herzen – branch of the Federal State Budgetary Institution “NMITs Radiology” of the Ministry of Health of Russia, 2022. 239 p. ISBN 978-5-85502-275-9 (In Russian)
7. Clinical guidelines approved by the scientific council of the Ministry of Health of the Russian Federation, Malignant neoplasms of the vagina, 2020. (In Russian) 8. American Cancer Society. Cancer Facts and Figures 2020. Atlanta, Ga: American Cancer Society; 2020. https://www.cancer.org/research/cancer-factsstatistics/all-cancer-facts-figures/cancer-factsfigures-2020.html
8. American Cancer Society. Cancer Facts and Figures 2020. Atlanta, Ga: American Cancer Society; 2020. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2020.htm
9. Aksenova S.P., Solodky V.A., Nudnov N.V. et al. Magneticresonance imaging in vaginal tumor diagnostics (based on the materials of methodological recommendations). Comprehensive magnetic resonance imaging in the differential diagnosis of tumor and non-tumor lesions of the vagina. Bulletin of the Scientific Center for Roentgen Radiology. 2022; 22 (2). (In Russian)
10. Kazumova A.A. Ultrasound diagnosis of tumors of the vagina and vulva: Dis. … Cand. of Med. Sci. Obninsk, 2010. 101 p. (In Russian)
11. Pozzati F., Moro F., Leombroni M. et al. Clinical and ultrasound characteristics of vaginal lesions. Int. J. Gynecol. Cancer. 2021; 31 (1): 45–51. https://doi.org/10.1136/ijgc-2020-001651
12. Fischerova D., Garganese G., Reina H. et al. Terms, definitions and measurements to describe sonographic features of lymph nodes: consensus opinion from the Vulvar International Tumor Analysis (VITA) group. Ultrasound Obstet. Gynecol. 2021; 57 (6): 861–879. https://doi.org/10.1002/uog.23617
13. Faria S., Devine C., Viswanathan C. et al. FDG-PET assessment of other gynecologic cancers. PET Clin. 2018; 13 (2): 203–223. https://doi.org/10.1016/j.cpet.2017.11.006
14. Robertson N.L., Hricak H., Sonoda Y. et al. The impact of FDG-PET/CT in the management of patients with vulvar and vaginal cancer. Gynecol. Oncol. 2016; 140 (3): 420–424. https://doi.org/10.1016/j.ygyno.2016.01.011
15. Gouveia P., Sá Pinto A., Violante L. et al. 18F-FDG PET/CT in Patients with Vulvar and Vaginal Cancer: A Preliminary Study of 20 Cases. Acta Med. Port. 2022; 35 (3): 170–175. https://doi.org/10.20344/amp.12510
16. Sadowski E.A., Pirasteh A., McMillan A.B. et al. PET/MR imaging in gynecologic cancer: tips for differentiating normal gynecologic anatomy and benign pathology versus cancer. Abdom. Radiol. (NY). 2022; 47 (9): 3189–3204. https://doi.org/10.1007/s00261-021-03264-9
17. Kilcoyne A., Gottumukkala R.V., Kang S.K. et al.; Expert Panel on GYN and OB Imaging. ACR Appropriateness Criteria® Staging and Follow-up of Primary Vaginal Cancer. J. Am. Coll. Radiol. 2021; 18: S442–S455. https://doi.org/10.1016/j.jacr.2021.08.011
18. Shetty A.S. Menias C.O. MR imaging of vulvar and vaginal cancer. Magn. Reson. Imaging Clin. N. Am. 2017; 25: 481–502. https://doi.org/10.1016/j.mric.2017.03.013
19. Ferreira D.M. Bezerra R.O.F. Ortega C.D. et al. Magnetic resonance imaging of the vagina: an overview for radiologists with emphasis on clinical decision making. Radiol. Bras. 2015; 48: 249–259. https://doi.org/10.1590/0100-3984.2013.1726
20. Parikh J.H., Barton D.P., Ind T.E., Sohaib S.A. MR imaging features of vaginal malignancies. Radiographics. 2008; 28 (1): 49–63; quiz 322. https://doi.org/10.1148/rg.281075065
21. Aksenova S.P., Nudnov N.V., Solodkiy V.A. Search for the optimal MRI protocol for the diagnosis of a tumor lesion of the vagina. Journal of Radiology and Nuclear Medicine. 2022; 103 (4–6): 58–70. https://doi.org/10.20862/0042-4676-2022-103-4-6-58-70 (In Russian)
22. Manganaro L., Lakhman Y., Bharwani N. et al. Staging, recurrence and follow-up of uterine cervical cancer using MRI: Updated Guidelines of the European Society of Urogenital Radiology after revised FIGO staging 2018. Eur. Radiol. 2021; 31 (10): 7802–7816. https://doi.org/10.1007/s00330-020-07632-9. Epub 2021 Apr 14. Erratum in: Eur Radiol. 2021 Jun 17.
23. Proscia N., Jaffe T.A., Neville A.M. et al. MRI of the pelvis in women: 3D versus 2D T2-weighted technique. Am. J. Roentgenol. 2010; 195 (1): 254–259. https://doi.org/10.2214/ajr.09.3226
24. Alt C.D., Bharwani N., Danza F.M. et al. ESUR Quick Guide to Female Pelvis Imaging. 2019; https://www.researchgate.net/publication/334725882_ESUR_Quick_Guide_to_Female_Pelvis_Imaging
25. Bhardwaj R., Boruah D.K., Gogoi B.B. et al. Added-Value of Diffusion-Weighted Imaging (DWI) and Dynamic Contrast-Enhanced (DCE-MRI) Magnetic Resonance Imaging in the Preoperative Assessment of Cervical Cancer. J. Obstet. Gynaecol. India. 2022; 72 (4): 330–340. https://doi.org/10.1007/s13224-021-01488-9
26. Chow L., Tsui B.Q., Bahrami S. et al. Gynecologic tumor board: a radiologist's guide to vulvar and vaginal malignancies. Abdom. Radiol. (NY). 2021; 46 (12): 5669–5686. https://doi.org/10.1007/s00261-021-03209-2
27. Lamoreaux W.T., Grigsby P.W., Dehdashti F. et al. FDG-PET evaluation of vaginal carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2005; 62 (3): 733–737. https://doi.org/10.1016/j.ijrobp.2004.12.011
28. Brar H., May T., Tau N. et al. Detection of extra-regional tumour recurrence with 18F-FDG-PET/CT in patients with recurrent gynaecological malignancies being considered for radical salvage surgery. Clin. Radiol. 2017; 72 (4): 302–306. https://doi.org/10.1016/j.crad.2016.12.009
29. ACR–SABI–SAR–SPR Practice parameter for the performance of computed tomography (CT) of the abdomen and computed tomography (CT) of the pelvis. Practice parameter. CT abdomen CT pelvis. revised 2021 (resolution 46)
30. Burton C.S., Frey K., Fahey F. et al. Fetal Dose from PET and CT in Pregnant Patients. J. Nucl. Med. 2023; 64 (2): 312–319. https://doi.org/10.2967/jnumed.122.263959
31. NCCN Clinical Practice Guidelines in Oncology. Cervical cancer. Version 1.2020. Available at. https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf
32. Nout R., Calaminus G., Planchamp F. et al. ESTRO/ESGO/ SIOPe guidelines for the management of patients with vaginal cancer. Radiother Oncol. 2023 Sep;186:109662. https://doi.org/10.1016/j.radonc.2023.109662
33. Friedman S.N., Itani M., Dehdashti F. PET Imaging for Gynecologic Malignancies. Radiol. Clin. N. Am. 2021; 59 (5): 813–833. https://doi.org/10.1016/j.rcl.2021.05.011
34. Gardner C.S., Sunil J., Klopp A.H. et al.Primary vaginal cancer: role of MRI in diagnosis, staging and treatment. Br. J. Radiol. 2015; 88 (1052): 20150033. https://doi.org/10.1259/bjr.20150033
35. Korzhevskaya E.V., Kuznetsov V.V., Gritsai A.N. Malignant tumors of the vagina. Clinical oncogynecology: A guide for physicians, / Ed. V.P. Kozachenko. 2nd ed., revised. and additional M.: Binom Publishing House, 2016: 97–108. (In Russian)
36. Choi H.J., Ju W., Myung S.K., Kim Y. Diagnostic performance of computer tomography, magnetic resonance imaging, and positron emission tomography or positron emission tomography/computer tomography for detection of metastatic lymph nodes in patients with cervical cancer: meta-analysis. Cancer Sci. 2010; 101 (6): 1471–1479. https://doi.org/10.1111/j.1349-7006.2010.01532.x
37. Albuquerque K.S., Zoghbi K.K., Gomes N.B.N. et al. Vaginal cancer: Why should we care? Anatomy, staging and in-depth imaging-based review of vaginal malignancies focusing on MRI and PET/CT. Clin. Imaging. 2022; 84: 65–78. https://doi.org/10.1016/j.clinimag.2022.01.009
38. Garganese G., Collarino A., Fragomeni S.M. et al. Groin sentinel node biopsy and 18F-FDG PET/CT-supported preoperative lymph node assessment in cN0 patients with vulvar cancer currently unfit for minimally invasive inguinal surgery: The GroSNaPET study. Eur. J. Surg. Oncol. 2017; 43 (9): 1776-1783. https://doi.org/10.1016/j.ejso.2017.06.018
Supplementary files
Review
For citations:
Solodkiy V.A., Nudnov N.V., Aksenova S.P., Rubtsova N.A., Sinitsyn V.E., Berezovskaia T.P., Ivashina S.V., Bychenko V.G., Mishchenko A.V., Khodzhibekova M.M., Chekalova M.A., Antonova I.B., Ashrafyan L.A., Novikova E.G., Krikunova L.I. Imaging of vaginal cancer. Consensus of experts. Medical Visualization. 2023;27(4):124-137. (In Russ.) https://doi.org/10.24835/1607-0763-1354