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Features of radiological manifestations in the diagnosis of nontuberculous mycobacteriosis. Literature review Сlinical observation

https://doi.org/10.24835/1607-0763-1352

Abstract

Purpose of the study. The purpose of this literature review is to determine the radiographic features in the diagnosis of non-tuberculous mycobacteriosis (NTMB) and to assess the possibility of radiological diagnosis of a combination of tuberculosis and non-tuberculous mycobacteriosis of the lungs in a patient with HIV infection.

Materials and methods. A review of the literature on the bases of scientific articles PubMed, ELibrary and Google Scholar. Attention was focused on full-text articles. The article presents a clinical observation of a patient being treated at the Clinical TB Dispensary in Omsk from 2019 to 2022 with a diagnosis of disseminated pulmonary tuberculosis, bilateral, in the infiltration phase, tuberculous spondylitis ThVII–IX, complicated by a paravertebral abscess.

Results. The radiological changes characteristic of NTMB are: lesion of the right middle and lingual lobes of the lungs with the presence of diffuse bronchiectasis, changes in the type of “tree in the kidneys”, compaction of lung tissue by the type of “frosted glass” with the presence of centrilobular nodules, asymmetric small dense foci with peribronchial location, apical location of thin-walled cavities with thickening of the costal pleura, as well as foci of inflammatory infiltration. The absence of specific symptoms for this pathology requires further research in this area. The identification of characteristic radiological features will speed up the diagnosis of infection and determine the correct management tactics for patients.

Conclusion. The radiosemiotics of NTMB is characterized by a large variability of manifestations. The most informative method of radiation diagnosis of NTMB is multispiral computed tomography (MSCT). Thanks to MSCT, a radiologist has the opportunity to accurately assess the localization and nature of foci, as well as assess the dynamics and prevalence of the process. The most characteristic radiological symptoms are the defeat of the right middle and lingual lobes of the lungs with the presence of diffuse bronchiectasis, changes in the type of “tree in the kidneys”, compaction of lung tissue by the type of “frosted glass” and the presence of centrilobular nodules, asymmetric small dense foci with peribronchial arrangement, apical arrangement of thin-walled cavities with thickening of the costal pleura, as well as foci inflammatory infiltration. The absence of specific symptoms for this pathology requires further research in this area. The identification of characteristic radiological features will speed up the diagnosis of infection and determine the correct management tactics for patients.

About the Authors

E. Yu. Khomutova
Omsk State Medical University
Russian Federation

Elena Yu. Khomutova – Doct. of Sci. (Med.), Head of the Department of Radiation Diagnostics

12, Lenina str., Omsk 644099

Phone: +7-3812-24-21-07



V. I. Porokh
Omsk State Medical University
Russian Federation

Vera I. Porokh – Postgraduate Student, Department of Radiation Diagnostics

12, Lenina str., Omsk 644099



P. V. Novikov
Omsk State Medical University
Russian Federation

Pavel V. Novikov – Cand. of Sci. (Med.), Associate Professor of the Department of Radiation Diagnostics

12, Lenina str., Omsk 644099



A. A. Uralbayev
Omsk State Medical University
Russian Federation

Alisher A. Uralbayev – Resident doctor of the Department of Radiation Diagnostics

12, Lenina str., Omsk 644099



References

1. Makarova M.V., Guntupova L.D. No ntuberculous Mycobacteria. BIOpreparations. Prevention, Diagnosis, Treatment. 2020; 20 (2): 97–102. https://doi.org/10.30895/2221-996X-2020-20-2-97-102 (In Russian)

2. Timpe A., Runyon E.H.. The relationship of atypical acidfast bacteria to human disease; a preliminary report. J. Lab. Clin. Med. 1954; 44 (2): 202–209. PMID: 13184228

3. Amansakhedov R.B., Lepekha L.N., Dmitrieva L.I. et al. X-ray morphological semiotics of non-tuberculous mycobacterial pulmonary disease. J. Radiol. Nucl. Med. 2018; 99 (4): 184–190. https://doi.org/10.20862/00424676-2018-99-4-184-190 (In Russian)

4. Eliseev P.I., Maryandyshev А.O., Tarasova I.V. et al. Diagnostics and treatment of pulmonary mycobacteriosis in the patients with suspected pulmonary tuberculosis. Tuberculosis and Lung Diseases. 2018; 96 (7): 61–62. https://doi.org/10.21292/2075-1230-2018-96-7-61-62 (In Russian)

5. Petrovа L.V., Melnikovа E.I., Soloviev Yu.A. et al. Detection of non-tuberculous mycobacteria in Mari El Republic. Tuberculosis and Lung Diseases. 2018; 96 (2): 41–46. https://doi.org/10.21292/2075-1230-2018-96-2-41-46 (In Russian)

6. Sokolina I.A. Imaging of pulmonary nontuberculous mycobacterial infection. Consilium Medicum. 2017; 19 (3): 24–28. (In Russian)

7. Mezhebovskiy V.R., Shmakova E.V., Mezhebovskiy A.V. et al. Prevalence of non-tuberculosis mycobacteria among the orenburg region population. Orenburg Medical Bulletin. 2022; 1 (37): 55–57. (In Russian)

8. Ueyama M., Asakura T., Morimoto K. et al. Pneumothorax associated with nontuberculous mycobacteria: A retrospective study of 69 patients. Medicine. 2016; 95 (29): e4246. doi:10.1097/MD.0000000000004246

9. Safianowska A., Walkiewicz R., Nejman-Gryz P. et al. Diagnostic utility of the molecular assay GenoType MTBC (HAIN Lifesciences, Germany) for identification of tuberculous mycobacteria. Pneumonologia i Alergologia Polska. 2009; 77 (6): 517–520.

10. Clinical recommendations. Mycobacteriosis of the respiratory system. 2022. https://spulmo.ru/upload/kr/Microbakterioz_2022.pdf (In Russian)

11. Amansakhedov R.B, Dmitrieva L.I., Smirnova T.G. et al. Radiological semiotics of different types of nontuberculous pulmonary mycobacterioses. Journal of Radiology and Nuclear Medicine. 2022; 103 (1–3): 30-37 https://doi.org/10.20862/0042-4676-2022-103-1-3-30-37 (In Russian)

12. Smolnikova U.A., Gavrilov P.V., Ushkov A.D. et al. Difficulties in diagnostics of a focal form of non-tuberculous mycobacteriosis. REJR. 2021; 11 (4): 158–163. https://doi.org/10.21569/2222-7415-2021-11-4-158-163 (In Russian)

13. Shmelev E.I., Zaitseva A.S., Makaryants N.N. et al. Patients with non-tuberculous mycobacteriosis in clinical practice. Pulmonologiya. 2022; 32 (1): 95–102. https://doi.org/10.18093/0869-0189-2022-32-1-95-102 (In Russian)

14. Bonnet M., San K.C., Pho Y. et al. Nontuberculous Mycobacteria Infections at a Provincial Reference Hospital, Cambodia. Emerging infectious diseases. 2017; 23 (7): 1139–1147. https://doi.org/10.3201/eid2307.170060

15. Bakuła Z., Kościuch J., Safianowska A. et al. Clinical, radiological and molecular features of Mycobacterium kansasii pulmonary disease. Respir. Med. 2018; 139: 91–100. https://doi.org/10.1016/j.rmed.2018.05.007

16. Brode S.K, Daley C.L., Marras T.K. The epidemiologic relationship between tuberculosis and non-tuberculous mycobac-terial disease: a systematic review. Int. J. Tuberc. Lung. Dis. 2014; 18 (11): 1370–1377. https://doi.org/10.5588/ijtld.14.0120

17. Sargsyan A.P., Makaryants N.N., Lepeha L.N., Chernousova L.N. Clinical and radiological manifestations of mycobacteriosis in patients with chronic lung diseases. Doctor.Ru. 2021; 20 (7): 66–72. https://doi.org/10.31550/1727-2378-2021-20-7-66-72 (In Russian)

18. Musaddaq B., Cleverley J.R. Diagnosis of non-tuberculous mycobacterial pulmonary disease (NTM-PD): Modern challenges. Br. J. Radiol. 2020; 93, 1106 20190768. https://doi.org/10.1259/bjr.20190768

19. Nqwata L., Ouédrago A.R. Non-tuberculous mycobacteria pulmonary disease: A review of trends, risk factors, diagnosis and management. Afr. J. Thorac. Crit. Care Med. 2022; 28 (2). https://doi.org/10.7196/AJTCCM.2022.v28i2.157

20. De Marca P.G.C., Goldenberg T., Mello F.C.Q. et al. Pulmonary Densitovolumetry Using Computed Tomography in Patients with Nontuberculous Mycobacteria: Correlation with Pulmonary Function Tests. Pulm. Med. 2019; 2019: 5942783. https://doi.org/10.1155/2019/5942783

21. Gavrilov P.V., Archakova L.I., Anisimova A.I., Kolesnichenko O.M. Radiation semiotics of mycobacteriosis of the lungs caused by Mycobacterium avium in immunocompetent patients. Medical Alliance. 2019; 1: 31–37. (In Russian)

22. Szturmowicz M., Oniszh K., Wyrostkiewicz D. et al. Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases-Colonization or Disease? Antibiotics (Basel). 2020; 9 (7): 424. https://doi.org/10.3390/antibiotics9070424

23. Sharma S.K. Diagnosis & treatment of non-tuberculous mycobacterial diseases. Indian J. Med. Res. 2020; 152 (3): 185–226. https://doi.org/10.4103/ijmr.IJMR_902_20

24. Yoon H.J., Choi H.Y. Nontuberculosis mycobacterial infections at a specialized tuberculosis treatment centre in the Republic of Korea. BMC Infect. Dis. 2017; 17 (1). 432.

25. Guntupova L.D., Borisov S.E., Makarova M.V., Hachaturyants E.N. Mycobacteriosis of the respiratory system: epidemiology, microbiology and clinical aspects of diagnosis. Epidemiology and Infectious Diseases. 2012; 17 (2): 8–14. https://doi.org/10.17816/EID40627 (In Russian)

26. Lepecha L.N., Krasnikova E.V. Tissue and cellular reactions of the lungs caused by various strains of slow-growing non-tuberculosis mycobacteria. Bulletin of “TSNIIT”. 2020; 4: 27–34. https://doi.org/10.7868/S2587667820040032 (In Russian)

27. Guntupova L.D., Borisov S.E., Solovyova I.P., et al. Mycobacterioses in phthisiopulmonological practice: literature review and own experience. Practical Medicine. 2011; 3–1 (50): 39–50. (In Russian)

28. Savchenko M. A. Clinical and epidemiological aspects of mycobacteriosis in patients with HIV infection. HIV Infection and Immunosuppression. 2019; 11 (2): 27–33. https://doi.org/10.22328/2077-9828-2019-11-2-27-33 (In Russian)

29. Mishina A.V., Mishin V.Yu., Sobkin A.L. Tuberculosis and mycobacteriosis of the lungs in patients with late stages of HIV infection. Tuberculosis and Lung Diseases. 2019; 97 (12): 58–59. https://doi.org/10.21292/2075-1230-2019-97-12-58-59 (In Russian)

30. Clinical recommendations “Tuberculosis in adults”. 2022–2023. https://edu.nmrc.ru/wp-content/uploads/2023/07/%D0%9A%D0%A016.pdf


Review

For citations:


Khomutova E.Yu., Porokh V.I., Novikov P.V., Uralbayev A.A. Features of radiological manifestations in the diagnosis of nontuberculous mycobacteriosis. Literature review Сlinical observation. Medical Visualization. 2024;28(1):97-109. (In Russ.) https://doi.org/10.24835/1607-0763-1352

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