Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art
https://doi.org/10.24835/1607-0763-1297
Abstract
Oxygen metabolism is a key factor in the life of a living organism. The article is the first part of a review of methods for measuring oxygen metabolism.
Purpose. The aim of this review is to present an insight into the evolution of methods for measuring oxygen metabolism in a way from global to local measurement of brain perfusion. The role of the 15O isotope as the “gold standard” for measuring oxygen metabolism using positron emission tomography (PET) is described. We also provide a case report of brain tumor perfusion measurements from our clinic.
Materials and methods. More than 200 Pubmed publications were studied with the keywords “positron emission tomography + O-15”. Relevant publications that do not contain these keywords or contain them in a different wording were also analyzed. A clinical case of a brain tumor perfusion using CT perfusion, MR-ASL and PET with H215O is provided.
Results. The evolution of methods for measuring perfusion, oxygen extraction, and oxygen metabolism, is described. More than 50 papers are cited depicting key advances in measurement technologies. Examples of the use of PET with H215O in fundamental research and clinical practice are given.
Conclusion. The obvious value of oxygen-isotope PET data is combined with the invasiveness (in some cases), technical complexity and high cost of the procedure. The second part of the review will be devoted to alternative methods for measuring oxygen metabolism, which are developing in the 21st century and which are intended for wide clinical use.
About the Authors
A. A. Postnov
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); Research Institute of Technical Physics and Automation (“NIITFA”); P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Andrey A. Postnov – Cand. of Sci. (Phys.-Math.), researcher of Department of X-ray and Radioisotope Diagnostic Methods; assistant professor; project leader; researcher
16, 4rd Tverskaya-Yamskaya str., Moscow 125047;
31, Kashirskoe shosse, Moscow 115230;
46, Varshavskoe shosse, Moscow 115230;
53, Leninsky prospect, Moscow 119991
D. B. Kalaeva
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Russian Federation
Russian Federation
Diana B. Kalaeva – Medical physicist of the Department of X-ray and Radioisotope Diagnostic Methods; graduate student
16, 4rd Tverskaya-Yamskaya str., Moscow 125047;
31, Kashirskoe shosse, Moscow 115230
A. B. Balakhonov
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Anton B. Balakhonov – Lead Engineer of the Department of X-ray and Radioisotope Diagnostic Methods
16, 4rd Tverskaya-Yamskaya str., Moscow 125047
I. N. Pronin
N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Igor’ N. Pronin – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Head of the Department of X-ray and Radioisotope Diagnostic Methods
16, 4rd Tverskaya-Yamskaya str., Moscow 125047
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For citations:
Postnov A.A., Kalaeva D.B., Balakhonov A.B., Pronin I.N. Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art. Medical Visualization. 2023;27(4):138-149. (In Russ.) https://doi.org/10.24835/1607-0763-1297
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