Concomitant intraductal papillary mucinous neoplasm (IPMN) and neuroendocrine tumor (NET) of pancreas
https://doi.org/10.24835/1607-0763-1030
Abstract
We present a rare clinical case of a 66-year-old woman who had two different synchronuos tumors of pancreas: intraductal papillary mucinous neoplasm (IPMN) and neuroendocrine cancer. The preoperative CT/MRI diagnosis was not too difficult, because of the typical presentations, but the combination of features was very unusual. A morphological examination after surgical operation followed by fine-needle biopsy confirmed the preoperative diagnosis of combined the two different tumors.
About the Authors
K. A. RomanovaRussian Federation
Ksenia A. Romanova – Cand. of Sci. (Med.), researcher of the Diagnostic radiology department
23, Kashirskoye shosse, 115478 Moscow
Phone: +7-926-079-20-00
A. B. Lukianchenko
Russian Federation
Alexander B. Lukianchenko – Doct. of Sci. (Med.), Professor, Leading researcher of the Diagnostic radiology department
Kashirskoe shousse, 23, 115478 Moscow
B. M. Medvedeva
Russian Federation
Bela M. Medvedeva – Doct. of Sci. (Med.), Leading researcher of the Diagnostic radiology department
Kashirskoe shousse, 23, 115478 Moscow
A. N. Polyakov
Russian Federation
Aleksander N. Polyakov – Cand. of Sci. (Med.), senior researcher of the Oncology department of surgical treatment methods №7 (tumors of the hepatopancreatobiliary zone) of N.N. Trapeznikov Clinical oncology institute
Kashirskoe shousse, 23, 115478 Moscow
References
1. WHO classification of tumours. 5th ed. Digestive system tumours edited by the WHO Classification of Tumours Editorial Board. Lyon, IARC Press, 2019.
2. Demos T.C., Posniak H.V., Harmath C., Olson M.C., Aranha G. Cystic Lesions of the Pancreas. Am J. Roentgenol. 2002; 179: 1375–1388. https://doi.org/10.2214/ajr.179.6.1791375
3. Sahani D.V., Kambadakone A., Macari M., Takahashi N., Chari S., Fernandez-del Castillo C. Diagnosis and Management of Cystic Pancreatic Lesions. Am J. Roentgenol. 2013; 200: 343–354. https://doi.org/10.2214/ajr.12.8862
4. Adsay N.V. Cystic neoplasia of the pancreas: pathology and biology. J. Gastrointest. Surg. 2008; 12 (3): 401–404. https://doi.org/10.1007/s11605-007-0348-z
5. Wang Yi., Miller F.H., Chen Z.E., Merrick L., Mortele K.J., Hoff F.L., Hammond N.A., Yaghmai V., Nikolaidis P. Diffusion-weighted MR Imaging of Solid and Cystic Lesions of the Pancreas. RadioGraphics. 2011; 31: 47–65. https://doi.org/10.1148/rg.313105174
6. Kucera J.N., Kucera S., Perrin S.D., Caracciolo J.T., Scmulewitz N., Kedar R.P. Cystic Lesions of the Pancreas: Radiologic-Endosonographic Correlation. RadioGraphics. 2012; 32: 283–301. https://doi.org/10.1148/rg.327125019
7. Salvia R., Fernández-del Castillo C., Bassi C., Thayer S.P., Falconi M., Matovania W., Pederzoli P., Warshaw A.L. Main-duct intraductal papillary mucinous neoplasms of the pancreas: Clinical predictors of malignancy and longterm survival following resection. Ann. Surg. 2004; 239: 678–687. https://doi.org/10.1097/01.sla.0000124386.54496.15
8. Tanaka M., Fernandez-del Castello C., Adsay V., Chari S., Falconi M., Jang J.Y., Kimura W., Levy P., Pitman M.B., Schmidt C.M., Shimizu M., Wolfgang C.L., Yamaguchi K., Yamao K. International Association of Pancreatology. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012; 12: 183–197. https://doi.org/10.1016/j.pan.2012.04.004
9. Hwang D.W., Jang J.Y., Lee S.E., Lim C.S., Lee K.U., Kim S.W. Clinicopathologic analysis of surgically proven intraductal papillary mucinous neoplasms of the pancreas in SNUH: A 15-year experience at a single academic institution. Langenbecks Arch. Surg. 2012; 397: 93–102. https://doi.org/10.1007/s00423-010-0674-6.
10. Lukyanchenko A.B., Romanova K.A. Modern approaches to imaging of focal pancreas lesions. Moscow, 2018. 112 p. (In Russian)
11. Machado N.O., al Qadhi H., al Wahibi K. Intraductal Papillary Mucinous Neoplasm of Pancreas. N. Am. J. Med. Sci. 2015; 7 (5): 160–175. https://doi.org/10.4103/1947-2714.157477
12. Jeurnink S.M., Vleggaar F.P., Siersema P.D. Overview of the clinical problem: Facts and current issues of mucinous cystic neoplasms of the pancreas. Dig. Liver Dis. 2008; 40: 837–46. https://doi.org/10.1016/j.dld.2008.03.018
13. Gupta R., Mortelé K.J., Tatli S., Girshman J., Glickman J.N., Levy A.D., Erturk S.M., Heffess C.S., Banks P.A, Stuart G. Pancreatic intraductal mucinous neoplasms: Role of CT in predicting pathologic subtypes. Am J. Roentgenol. 2008; 191: 1458–1464. https://doi.org/10.2214/ajr.07.3302
14. Tan E.H. Imaging of gastroenteropancreatic neuroendocrine tumors. Wld J. Clin. Oncol. 2011; 2 (1): 28–43. https://doi.org/10.5306/wjco.v2.i1.28
15. Oberg K. Pancreatic endocrine tumors. Sem. Oncol. 2010; 37 (6): 594–618. https://doi.org/10.1053/j.seminoncol.2010.10.014
16. Noone T.C., Hosey J., Firat Z., Semelka R.C. Imaging and localization of islet-cell tumours of the pancreas on CT and MRI. Best Pract. Res. Clin. Endocrinol. Metab. 2005; 19 (2): 195–211. https://doi.org/10.1016/j.beem.2004.11.013
17. Stepanova J.A., Dubova E.A., Karmazanovsky G.G., Sidorova E.E., Ikramov R.Z. Radiology Diagnostics of Neuroendocrine Tumors of the Pancreas with Cystic Transformation of Structure. Medical Visualization. 2009; 4: 98–109. (In Russian)
18. Ishida M., Shiomi H., Naka S., Tani T., Okabe H. Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas. Oncol. Lett. 2013; 5: 63–67 (In Japan).
19. Vazquez A.M., Ramia J.M., Lattore-Fragua R., ValleRubio A., Arteaga-Peralta V., Ramiro-Perez C., PlazaLlamas R.P. Pancreatic Neuroendocrine Tumors and Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review. Pancreas. 2018; 47 (5): 551–555. https://doi.org/10.1097/mpa.0000000000001048
Supplementary files
Review
For citations:
Romanova K.A., Lukianchenko A.B., Medvedeva B.M., Polyakov A.N. Concomitant intraductal papillary mucinous neoplasm (IPMN) and neuroendocrine tumor (NET) of pancreas. Medical Visualization. 2021;25(3):43-49. (In Russ.) https://doi.org/10.24835/1607-0763-1030