References

medvis

Медицинская визуализация

Medical Visualization

1607-07632408-9516

RDS-Media Ltd.

10.24835/1607-0763-2018-5-6-13

medvis-649

Research Article

ГОЛОВА И ШЕЯ

HEAD AND NECK

Функциональная МРТ покоя головного мозга в предоперационном планировании. Обзор литературы

Resting state fMRI in pre-surgical brain mapping. Literature review

Смирнов

А. С.

Smirnov

A. S.

врач отделения рентгеновских и радиоизотопных методов

+7-926-905-55-61

125047 Москва, ул. 4-я Тверская-Ямская, д. 16. Отделение рентгеновских и изотопных методов диагностики

med. doctor of Neuroradiology department

125047 Moscow, 4-th Tverskaya-Yamskaya str., 16, Burdenko National Scientific and Practical Center for Neurosurgery, Neuroradiology department

+7-926-905-55-61

alex.s.smirnof@gmail.com

Шараев

М. Г.

Sharaev

M. G.

канд. физ.-мат. наук, научный сотрудник

cand. of phys-math. sci., researcher of CDISE

Мельникова-Пицхелаури

Т. В.

Melnikova-Pitskhelauri

T. V.

канд. биол. наук, ведущий инженер отделения рентгеновских и радиоизотопных методов диагностики

cand. of biol. sci., lead. engineer of Neuroradiology department

Жуков

В. Ю.

Zhukov

V. Yu.

канд. мед. наук, врач VII нейрохирургического отделения

cand. of med. sci., med. doctor of 7 Neurosurgery department

Быканов

А. Е.

Bikanov

A. E.

канд. мед. наук, младший научный сотрудник 7 нейрохирургического отделения

cand. of med. sci., jr. researcher of 7 Neurosurgery department

Шарова

Е. В.

Sharova

E. V.

доктор биол. наук, заведующая лабораторией общей и клинической нейрофизиологии

doct. of biol. sci., Head of the Laboratory of common and clinical neurophysiology

Погосбекян

Э. Л.

Pogosbekyan

E. L.

мед. физик отделения рентгеновских и радиоизотопных методов диагностики

med. physicist of Neuroradiology department

Туркин

А. М.

Turkin

A. M.

канд. мед. наук, старший научный сотрудник отделения рентгеновских и радиоизотопных методовдиагностики

cand. of med. sci., senior researcher of Neuroradiology department

Фадеева

Л. М.

Fadeeva

L. M.

ведущий инженер отделения рентгеновских и радиоизотопных методов диагностики

lead. engineer of Neuroradiology department

Пицхелаури

Д. И.

Pitskhelauri

D. V.

доктор мед. наук, заведующий 7 нейрохирургическим отделением

doct. of med. sci., Head of 7 Neurosurgery department

Корниенко

В. Н.

Kornienko

V. N.

академик РАН, доктор мед. наук, профессор, научный консультант, отделение рентгеновских и радиоизотопных методов диагностики

Full Мember of the Russian Academy of Sciences, doct. of med. sci., Professor, Сonsultant, Neuroradiology department

Пронин

И. Н.

Pronin

I. N.

академик РАН, доктор мед. наук, профессор, заведующий отделением рентгеновских и радиоизотопных методов диагностики, заместитель директора по науке

Full Мember of the Russian Academy of Sciences, doct. of med. sci., Professor, Head of Neuroradiology department, Deputy Director

ФГАУ “Национальный медицинский исследовательский центр нейрохирургии имени академика Н.Н. Бурденко”РоссияFederal State Autonomous Institution “N.N. Burdenko National Medical Research Center of Neurosurgery"Russian Federation

Сколковский институт науки и технологий, МоскваРоссияSkolkovo Institute of Science and TechnologyRussian Federation

Институт высшей нервной деятельности и нейрофизиологии РАНРоссияInstitute of Higher Nervous Activity and NeurophysiologyRussian Federation

2018

28102018

05613

2018

Смирнов А.С., Шараев М.Г., Мельникова-Пицхелаури Т.В., Жуков В.Ю., Быканов А.Е., Шарова Е.В., Погосбекян Э.Л., Туркин А.М., Фадеева Л.М., Пицхелаури Д.И., Корниенко В.Н., Пронин И.Н.

Smirnov A.S., Sharaev M.G., Melnikova-Pitskhelauri T.V., Zhukov V.Y., Bikanov A.E., Sharova E.V., Pogosbekyan E.L., Turkin A.M., Fadeeva L.M., Pitskhelauri D.V., Kornienko V.N., Pronin I.N.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://medvis.vidar.ru/jour/article/view/649

В настоящее время функциональная магнитно-резонансная томография (фМРТ) позволяет планировать оперативное вмешательство с учетом топографии функционально значимых зон коры головного мозга и опухоли. Этот метод может дополнить стратегию хирургического лечения значимой клинической информацией. Как правило, для предоперационного планирования используется стимулзависимая фМРТ с двигательными и речевыми парадигмами. Результат исследования во многом зависит от способности пациентавыполнять задания парадигм, которые нарушаются при опухолях головного мозга. В попытке преодоления этойпро блемы используется метод фМРТ в состоянии покоя (рс-фМРТ, resting-state fMRI) с картированием функционально значимых зон. рс-фМРТ основана на измерении спонтанных колебаний BOLD сигнала (blood oxygen level-dependent), отражающего функциональное строение мозга. В отличие от стимулзависимой фМРТ рс-фМРТ предоставляет более полную информацию о функциональной архитектуре мозга и применяется в условиях, когда результаты стимулзависимой фМРТ могут быть ложноположительными или при отсутствии возможности ее выполнения. В совокупности оба ме тода существенно расширяют эффективность и специфичность предоперационного планирования.

Today, functional magnetic resonance imaging (fMRI) allows to plan surgery based on the topography of functionally important areas of the human brain cortex and tumor. This method can complement the surgical strategy with significant clinical information. The stimulus-dependent fMRI with motor and language paradigms is generally used for preoperative planning. The study outcome depends on the patient's ability to perform tasks paradigm, which is broken in brain tumors. In an attempt to overcome this problem, resting-state fMRI (rs-fMRI) is used for brain mapping. Rs-fMRI is based on the measurement of spontaneous fluctuations of the BOLD signal (blood oxygen level-dependent), representing the functional structure of the brain. In contrast to stimulus-dependent fMRI, rs-fMRI provides more complete information about functional architecture of the brain. rs-fMRI is used in conditions where the results of stimulusdependent fMRI may be falsely positive or in the absence of the possibility of its implementation. In aggregate, both methods significantly expand the efficiency and specificity of preoperative planning.

МРТ головного мозгафункциональная МРТфМРТ покояпредоперационное планированиекартирование мозга

human brain MRIfunctional MRIrestingstate fMRIpresurgical planningbrain mapping

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The authors declare that there are no conflicts of interest present.