medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.medvis-229Research ArticleБРЮШНАЯ ПОЛОСТЬABDOMENОнкоцитарный вариант внутрипротоковой папиллярной опухоли желчного протокаIntraductal Oncocytic Papillary Tumors of the Bile DuctШабунинАлексей ВасильевичShabuninAlexey Vasilevichnoemail@neicon.ruПаклинаОксана ВладимировнаPaklinaOxana Vladimirovnanoemail@neicon.ruСетдиковаГалия РавилевнаSetdikovaGaliya Ravilevnadr.setdikeva@mail.ruТавобиловМихаил МихайловичTavobilovMikhail Mikhailovichnoemail@neicon.ruАраблинскийАндрей ВладимировичArablinskyAndrey Vladimirovichnoemail@neicon.ruЛебедевСергей СергеевичLebedevSergey Sergeevichnoemail@neicon.ruГрековДмитрий НиколаевичGrekovDmitri Nikolaevichnoemail@neicon.ruГБУЗ “Городская клиническая больница им. С.П. Боткина”РоссияS.P. Botkin Clinical HospitalRussian Federation201528102015054551Copyright © Шабунин А.В., Паклина О.В., Сетдикова Г.Р., Тавобилов М.М., Араблинский А.В., Лебедев С.С., Греков Д.Н., 20152015Шабунин А.В., Паклина О.В., Сетдикова Г.Р., Тавобилов М.М., Араблинский А.В., Лебедев С.С., Греков Д.Н.Shabunin A.V., Paklina O.V., Setdikova G.R., Tavobilov M.M., Arablinsky A.V., Lebedev S.S., Grekov D.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.vidar.ru/jour/article/view/229

Внутрипротоковые папиллярные опухоли желчного протока (ВПО ЖП) - это собирательный термин, используемый для обозначения папиллярных опухолей желчных протоков, муцинпродуцирующих опухолей желчных протоков и кистозных опухолей желчных протоков. По аналогии с внутрипротоковыми папиллярными муцинозными опухолями поджелудочной железы выделены 4 гистологических типа ВПО ЖП на основании различий в экспрессии муцинов. В статье приведен редкий случай ВПО ЖП опухоли желчного протока, онкоцитарный вариант. Прогноз ВПО ЖП не ясен, несомненно, у пациентов без инвавзивного компонента прогноз более благоприятный по сравнению с ВПО ЖП в сочетании с инвазивной карциномой.

Intraductal papillary neoplasms of the bile duct (IPNBs) is a collective term for such neoplasms and bile-duct mucin-producing and cystic tumors. Similar to intraductal papillary mucinous tumors of pancreas, authors identify 4 histologic types of IPNB based on mucin expression differences. We describe a rare case of intraductal oncocytic papillary neoplasms of the bile duct. Prognosis for IPNB is unclear; however, no doubt, it is more favourable for patients without an invasive component compared with IPNb combined with invasive carcinoma.

желчные протокивнутрипротоковая опухольмуциныкомпьютерная томографияbile ductsintraductal tumormucinscomputer tomographyReferencesTerada T., Mitsui T., Nakanuma Y. et al. Intrahepatic biliary papillomatosis arising in nonobstructive intrahepatic biliary dilatations confined to the hepatic left lobe. Am. J. Gastroenterol. 1991; 86 (10): 1523-1526.Terada T., Mitsui T., Nakanuma Y. et al. Intrahepatic biliary papillomatosis arising in nonobstructive intrahepatic biliary dilatations confined to the hepatic left lobe. Am. J. Gastroenterol. 1991; 86 (10): 1523-1526.Shibahara H., Tamada S., Goto M. et al. Prognostic features of mucin-producing bile duct tumors. Two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. Am. J. Surg. Pathol. 2004; 28 (3): 327-338.Shibahara H., Tamada S., Goto M. et al. Prognostic features of mucin-producing bile duct tumors. Two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. Am. J. Surg. Pathol. 2004; 28 (3): 327-338.Kuo C., Changchien C., Wu K. et al. Mucin-producing cholangiocarcinoma: clinical experience of 24 cases in 16 years. Scand. J. Gastroenterol. 2005; 40 (4): 455-459.Kuo C., Changchien C., Wu K. et al. Mucin-producing cholangiocarcinoma: clinical experience of 24 cases in 16 years. Scand. J. Gastroenterol. 2005; 40 (4): 455-459.Yeh T., Tseng J., Chiu C. et al. Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts. Ann. Surg. 2006; 244 (2): 248-253.Yeh T., Tseng J., Chiu C. et al. Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts. Ann. Surg. 2006; 244 (2): 248-253.Bosman F.T. WHO Classification of tumors of the digestive system. Lyon, 2010. 417 p.Bosman F.T. WHO Classification of tumors of the digestive system. Lyon, 2010. 417 p.Rocha F.G., Lee H., Katabi N. et al. Intraductal papillary neoplasm of the bile duct: a biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? Hepatology. 2012; 56 (4): 1352-1360.Rocha F.G., Lee H., Katabi N. et al. Intraductal papillary neoplasm of the bile duct: a biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? Hepatology. 2012; 56 (4): 1352-1360.Wan X.-S., Xu Y.-Y., Qian J.-Y. Intraductal papillary neoplasm of the bile duct. Wld J. Gastroenterol. 2013; 19 (46): 8595-8604.Wan X.-S., Xu Y.-Y., Qian J.-Y. Intraductal papillary neoplasm of the bile duct. Wld J. Gastroenterol. 2013; 19 (46): 8595-8604.Kuwatani M., Kawakami H., Zen Y. et al. Difference from bile duct cancer and relationship between bile duct wall thickness and serum IgG/IgG4 levels in IgG4-related sclerosing cholangitis. Hepato-Gastroenterology. 2014; 61: 1852-1856.Kuwatani M., Kawakami H., Zen Y. et al. Difference from bile duct cancer and relationship between bile duct wall thickness and serum IgG/IgG4 levels in IgG4-related sclerosing cholangitis. Hepato-Gastroenterology. 2014; 61: 1852-1856.Kitano M., Kamata K., Imai H. Contrast-enhanced harmonic endoscopic ultrasonography for pancreatobiliary diseases. Dig. Endosc. 2015; 27: 60-67.Kitano M., Kamata K., Imai H. Contrast-enhanced harmonic endoscopic ultrasonography for pancreatobiliary diseases. Dig. Endosc. 2015; 27: 60-67.Lee S.S., Kim M., Lee S.K. et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 2004; 100 (4): 783-793.Lee S.S., Kim M., Lee S.K. et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 2004; 100 (4): 783-793.Yoon H.J., Kim Y.K., Jang K.T. et al. Intraductal papillary neoplasm of the bile ducts: description of MRI and added value of diffusion-weighted MRI. Abdom. Imaging. 2013; 38 (5): 1082-1090.Yoon H.J., Kim Y.K., Jang K.T. et al. Intraductal papillary neoplasm of the bile ducts: description of MRI and added value of diffusion-weighted MRI. Abdom. Imaging. 2013; 38 (5): 1082-1090.Chung Y.E., Kim M.J., Park Y.N. et al. Varying appearances of cholangiocarcinoma: radiologic-pathologic correlation. Radiographics. 2009; 29: 683-700.Chung Y.E., Kim M.J., Park Y.N. et al. Varying appearances of cholangiocarcinoma: radiologic-pathologic correlation. Radiographics. 2009; 29: 683-700.Kim K.M., Lee J.K., Shin J.U. et al. Clinicopathologic features of intraductal papillary neoplasm of the bile duct according to histologic subtype. Am. J. Gastroenterol. 2012; 107: 118-125.Kim K.M., Lee J.K., Shin J.U. et al. Clinicopathologic features of intraductal papillary neoplasm of the bile duct according to histologic subtype. Am. J. Gastroenterol. 2012; 107: 118-125.Song F., Zhou J., Shi Y. et al. Value of MR imaging in the diagnosis of intraductal papillary neoplasm of the bile duct. Zhonghua Zhong Liu Za Zhi. 2015; 37: 57-62.Song F., Zhou J., Shi Y. et al. Value of MR imaging in the diagnosis of intraductal papillary neoplasm of the bile duct. Zhonghua Zhong Liu Za Zhi. 2015; 37: 57-62.Wolf H.K., Garcia J.A., Bossen E.H. Oncocytic differentiation in intrahepatic biliary cystadenocarcinoma. Mod. Pathol. 1992; 5: 665-668.Wolf H.K., Garcia J.A., Bossen E.H. Oncocytic differentiation in intrahepatic biliary cystadenocarcinoma. Mod. Pathol. 1992; 5: 665-668.Martin R.C., Klimstra D.S., Schwartz L. et al. Hepatic intraductal oncocytic papillary carcinoma. Cancer. 2002; 95: 2180-2187.Martin R.C., Klimstra D.S., Schwartz L. et al. Hepatic intraductal oncocytic papillary carcinoma. Cancer. 2002; 95: 2180-2187.Spector S.A., Bejarano P.A., Amortegui J.D. et al. Intraductaloncocytic papillary neoplasm of the extrahepatic biliary tree: first report. Am. Surg. 2004; 70 (1): 55-58.Spector S.A., Bejarano P.A., Amortegui J.D. et al. Intraductaloncocytic papillary neoplasm of the extrahepatic biliary tree: first report. Am. Surg. 2004; 70 (1): 55-58.Terada T., Taniguchi M. Intraductal oncocytic papillary neoplasm of the liver. Pathol. Internat. 2004; 54: 116-123.Terada T., Taniguchi M. Intraductal oncocytic papillary neoplasm of the liver. Pathol. Internat. 2004; 54: 116-123.Tabibian J.H., Lassman C.R., Margolis D.J. et al. Intraductaloncocytic papillary neoplasm of the liver: case and review of a rare variant. Ann. Hepatol. 2008; 7: 168-173.Tabibian J.H., Lassman C.R., Margolis D.J. et al. Intraductaloncocytic papillary neoplasm of the liver: case and review of a rare variant. Ann. Hepatol. 2008; 7: 168-173.Lee S., Kim Y.S., Lee W.J. et al. Intraductaloncocytic papillary neoplasm of the bile duct: ultrasonography and CT findings with pathological correlations. Clin. Radiol. 2009; 64: 841-844.Lee S., Kim Y.S., Lee W.J. et al. Intraductaloncocytic papillary neoplasm of the bile duct: ultrasonography and CT findings with pathological correlations. Clin. Radiol. 2009; 64: 841-844.Nakanishi Y., Zen Y., Hirano S. et al. Intraductaloncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin. J. Hepatobil. Pancreat. Surg. 2009; 16: 869-873.Nakanishi Y., Zen Y., Hirano S. et al. Intraductaloncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin. J. Hepatobil. Pancreat. Surg. 2009; 16: 869-873.Tanaka M., Fukushima N., Noda N. et al. Intraductaloncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases. Hum. Pathol. 2009; 40: 1543-1552.Tanaka M., Fukushima N., Noda N. et al. Intraductaloncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases. Hum. Pathol. 2009; 40: 1543-1552.Cocieru A., Kesha K., El-Fanek H. et al. Hepatic intraductaloncocytic papillary carcinoma. Am. J. Surg. 2010; 199: e57-58.Cocieru A., Kesha K., El-Fanek H. et al. Hepatic intraductaloncocytic papillary carcinoma. Am. J. Surg. 2010; 199: e57-58.Watanabe A., Suzuki H., Kubo N. An Oncocytic Variant of Intraductal Papillary Neoplasm of the Bile Duct that Formed a Giant Hepatic Cyst. Rare Tumors. 2013; 5 (3): e30.Watanabe A., Suzuki H., Kubo N. An Oncocytic Variant of Intraductal Papillary Neoplasm of the Bile Duct that Formed a Giant Hepatic Cyst. Rare Tumors. 2013; 5 (3): e30.

The authors declare that there are no conflicts of interest present.