<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1424</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1424</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГОЛОВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEAD</subject></subj-group></article-categories><title-group><article-title>Толщина структур век в различных возрастных группах по данным ультразвукового исследования</article-title><trans-title-group xml:lang="en"><trans-title>Thickness of the eyelid structures in different age groups based on the ultrasound study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1134-8064</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гущина</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Gushchina</surname><given-names>M. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гущина Марина Борисовна – канд. мед. наук, врач-офтальмолог калужского филиала ФГАУ НМИЦ “МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова” Минздрава России, Калуга. https://orcid.org/0000-0003-1134-8064</p></bio><bio xml:lang="en"><p>Marina B. Gushchina – Cand. of Sci. (Med.), ophthalmologist, Kaluga branch S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga. https://orcid.org/0000-0003-1134-8064</p></bio><email xlink:type="simple">mbg1411@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3268-0982</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Надточий</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nadtochiy</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Надточий Андрей Геннадьевич – доктор мед. наук, профессор, заведующий отделом лучевой диагностики ФГБУ НМИЦ “Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии” Минздрава России, Москва. https://orcid.org/0000-0002-3268-0982</p></bio><bio xml:lang="en"><p>Andrey G. Nadtochiy – Doct. of Sci. (Med.),  Professor, Head of Diagnostic Radiology Unit, Central Research Institute of Dental and Maxillofacial Surgery, Moscow. https://orcid.org/0000-0002-3268-0982</p></bio><email xlink:type="simple">naggan@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0840-2675</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Терещенко Александр Владимирович – доктор мед. наук, профессор, директор калужского филиала ФГАУ НМИЦ “МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова” Минздрава России, Калуга. https://orcid.org/0000-0002-0840-2675</p></bio><bio xml:lang="en"><p>Alexander V. Tereshchenko – Doct. of Sci. (Med.), Professor, Director of Kaluga branch S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga. https://orcid.org/0000-0002-0840-2675</p></bio><email xlink:type="simple">nauka@mntk.kaluga.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6950-6497</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Афанасьева</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Afanasyeva</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Афанасьева Дарья Сергеевна – канд. мед. наук, врач­офтальмолог АО “Лечебно­диагностическое отделение клиники микрохирургии глаза «Окулист»”, Новосибирск.  https://orcid.org/0000-0001-6950-6497</p></bio><bio xml:lang="en"><p>Daria S. Afanasyeva – Cand. of Sci. (Med.), ophthalmologist, Treatment and Diagnostics Department of Eye Microsurgery Clinic “Okulist”, Novosibirsk. https://orcid.org/0000-0001-6950-6497</p></bio><email xlink:type="simple">ada-tomsk@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАУ НМИЦ “МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова” Минздрава России, Калужский филиал; 248007 Калуга, ул. им. Святослава Фёдорова, д. 5, Росийская Федерация<country>Россия</country></aff><aff xml:lang="en">S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga branch; 5, Svyatoslav Fyodorov str., Kaluga 248007, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ НМИЦ “Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии” Минздрава России; 119021 Москва, ул. Тимура Фрунзе, д. 16, Росийская Федерация</aff><aff xml:lang="en">Central Research Institute of Dental and Maxillofacial Surgery; 16, Timur Frunze str., Moscow 119021, Russian Federation</aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">АО “Лечебно­диагностическое отделение клиники микрохирургии глаза «Окулист»”; 630091 Новосибирск, ул.Крылова, д. 4, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Treatment and Diagnostics Department of Eye Microsurgery Clinic “Okulist”; 4, Krylova str., Novosibirsk 630091, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>03</day><month>11</month><year>2024</year></pub-date><volume>28</volume><issue>4</issue><fpage>26</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гущина М.Б., Надточий А.Г., Терещенко А.В., Афанасьева Д.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Гущина М.Б., Надточий А.Г., Терещенко А.В., Афанасьева Д.С.</copyright-holder><copyright-holder xml:lang="en">Gushchina M.B., Nadtochiy A.G., Tereshchenko A.V., Afanasyeva D.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.vidar.ru/jour/article/view/1424">https://medvis.vidar.ru/jour/article/view/1424</self-uri><abstract><p>Знание прижизненной толщины структур век человека помогает при диагностике и планировании хирургического вмешательства. Однако веки подвержены естественным возрастным изменениям, как и другие мягкие ткани лица.</p><sec><title>Цель исследования</title><p>Цель исследования: сравнить нормальную толщину структур век, измеренную с помощью ультразвукового исследования, в разных возрастных группах.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В проспективное наблюдение включены интактные веки с одной стороны лица 37 человек европеоидной популяции обоих полов в возрасте 27–79 лет. Выделены четыре группы с интервалом 10 лет в диапазоне 20–60 лет и группа лиц старше 60 лет. Измерения были сделаны при ультразвуковом B-сканировании одним опытным оператором.</p></sec><sec><title>Результаты</title><p>Результаты. Определена толщина кожи, круговой мышцы, конъюнктивы, тарзуса, их комплекса на разных уровнях верхнего и нижнего века, комплекса леватор-мышца Мюллера и мышцы Риолана, а также общая толщина век для каждой возрастной группы. Установлено, что прослеживаются возрастные особенности по всем параметрам, однако наиболее существенно изменяются два из них. Толщина кожи нижнего века в возрасте 31–40 лет (1,2 [1,0; 1,4] мм) значительно отличалась от значений в возрасте 41–50 лет (1,65[1,45; 1,85] мм и 51–60 лет (2,05 [1,73; 2,7] мм. Также конъюнктива на уровне пальпебральной складки верхнего века после 60 лет (0,97 [0,8; 1,2] мм) становилась значительно толще, чем у более молодых лиц особенно в возрасте 21–30 лет (0,49 [0,44; 0,55] мм, p = 0,053) и 41–50 лет (0,58 [0,50; 0,65] мм, p = 0,05).</p></sec><sec><title>Заключение</title><p>Заключение. Значительные отличия толщины кожи нижнего века выявлены в группе 31–40 лет от значений в группах 41–50 лет (p = 0,03) и 51–60 лет (p = 0,05). У лиц старше 60 лет конъюнктива верхнего века на уровне верхнего края тарзальной пластинки (ТП) была значительно толще, чем у лиц более молодых возрастных групп. Отмечено, что большинство структур верхнего века (кожа, конъюнктива, ТП, комплекс конъюнктива-ТП, круговая мышца глаза и общая толщина века на уровне ТП) во всех возрастных группах намного тоньше (p &lt; 0,05) соответствующих структур нижнего века. Полученные данные могут служить ориентиром при диагностике и планировании хирургических вмешательств.</p></sec></abstract><trans-abstract xml:lang="en"><p>Most of the literature data on eyelid structures are based on the measurements in cadavers or histological samples. Nonetheless, such data can differ from the living tissues with interstitial fluid and filled vessels. In clinical work, specialists sometimes need to be aware of the in vivo parameters of eyelids tissue structures.</p><p>Information on live thickness of eyelid structures supports diagnostic process and surgery planning. Nonetheless, the eyelids are affected by age related changes as other facial soft tissues.</p><sec><title>Purpose</title><p>Purpose: To compare thickness of normal eyelid structures measured with ultrasound in various age groups.</p></sec><sec><title>Methods</title><p>Methods. This prospective observational study was comprised of intact eyelids of 37 patients with a mean age of 46 ± 13.13 years (aged 27–79 years; 28 women). All subjects were divided into 4 groups with an interval of 10 years from 20 to 60 years and a group of aged above 60 years. Same operator took measurements skin, circular eye muscle, conjunctiva, tarsus and their composition of both eyelids with B-scan ultrasonography.</p></sec><sec><title>Results</title><p>Results. We established some age-related trends for all parameters, but two of them change the most significantly. The lower eyelid skin thickness in group of 31–40 years old people (1.2 [1.0;1.4] mm) significantly differed from the values in the groups of people aged 41–50 (1.65 [1.45;1.85] mm and 51–60 лет (2.05 [1.73;2.7] мм. Upper eyelid conjunctiva at the level of tarsal plate upper margin also tends to be thicker in people( older 60 years (0.97 [0.8;1.2] mm) than in younger adults, especially at the age of 21–30 (0.49 [0.44;0.55], p = 0.053) and 41-50 y.o. (0.58 [0.50;0.65] mm, p = 0.053).</p></sec><sec><title>Conclusion</title><p>Conclusion. Significant differences in the skin thickness of the lower eyelid were detected in the group of 31–40 years from the values in the groups of 41–50 years (p = 0.03) and 51–60 years (p = 0.05). In persons over 60 years of age, the conjunctiva of the upper eyelid at the level of the upper edge of the TP was significantly thicker than in younger age groups. It was noted that most of the structures of the upper eyelid (skin, conjunctiva, TP, conjunctiva-TP complex, orbicularis oculi muscle and the total thickness of the eyelid at the level of TP) in all age groups are much thinner (p &lt;0.05) than the corresponding structures of the lower eyelid. The obtained data can serve as a guide for diagnosis and planning of surgical interventions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>веки</kwd><kwd>круговая мышца глаза</kwd><kwd>леватор</kwd><kwd>мышца Риолани</kwd><kwd>блефаропластика</kwd><kwd>старение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>eyelids</kwd><kwd>orbicularis oculi muscle</kwd><kwd>levator</kwd><kwd>Riolani muscle</kwd><kwd>blepharoplasty</kwd><kwd>aging</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Masiwa L.E., Moodley V. A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus. J. Optom. 2020; 13 (4): 269–275. https://doi.org/10.1016/j.optom.2019.11.001</mixed-citation><mixed-citation xml:lang="en">Masiwa L.E., Moodley V. A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus. J. Optom. 2020; 13 (4): 269–275. https://doi.org/10.1016/j.optom.2019.11.001</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Potop V., Coviltir V., Schmitzer S. et al.Ultrasound biomicroscopy in glaucoma assessment. Rom. J. Ophthalmol. 2021; 65 (2): 114–119. https://doi.org/10.22336/rjo.2021.24</mixed-citation><mixed-citation xml:lang="en">Potop V., Coviltir V., Schmitzer S. et al.Ultrasound biomicroscopy in glaucoma assessment. Rom. J. Ophthalmol. 2021; 65 (2): 114–119. https://doi.org/10.22336/rjo.2021.24</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Alexander J.L., Wei L., Palmer J. et al. A systematic review of ultrasound biomicroscopy use in pediatric ophthalmology. Eye (Lond.). 2021; 35 (1): 265–276. https://doi.org/10.1038/s41433-020-01184-4</mixed-citation><mixed-citation xml:lang="en">Alexander J.L., Wei L., Palmer J. et al. A systematic review of ultrasound biomicroscopy use in pediatric ophthalmology. Eye (Lond.). 2021; 35 (1): 265–276. https://doi.org/10.1038/s41433-020-01184-4</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ochmann A., Winder M., Nalewajka-Kołodziejczak J., Chudek J. Current imaging methods for assessing Graves` orbitopathy activity with particular emphasis on FDG-PET. Front. Endocrinol. (Lausanne). 2023; 14: 1138569. https://doi.org/10.3389/fendo.2023.1138569</mixed-citation><mixed-citation xml:lang="en">Ochmann A., Winder M., Nalewajka-Kołodziejczak J., Chudek J. Current imaging methods for assessing Graves` orbitopathy activity with particular emphasis on FDG-PET. Front. Endocrinol. (Lausanne). 2023; 14: 1138569. https://doi.org/10.3389/fendo.2023.1138569</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Demirci H., Nelson C.C. Ultrasound biomicroscopy of the upper eyelid structures in normal eyelids. Ophthalmic. Plast. Reconstr. Surg. 2007; 23 (2): 122–125. https://doi.org/10.1097/IOP.0b013e31802f2074</mixed-citation><mixed-citation xml:lang="en">Demirci H., Nelson C.C. Ultrasound biomicroscopy of the upper eyelid structures in normal eyelids. Ophthalmic. Plast. Reconstr. Surg. 2007; 23 (2): 122–125. https://doi.org/10.1097/IOP.0b013e31802f2074</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Киселева Т.Н., Катаев М.Г., Ильина Н.В., Захарова М.А., Рамазанова К.А. Метод ультразвукового сканирования в оценке состояния век. Вестник офтальмологии. 2014; 1: 46–51.</mixed-citation><mixed-citation xml:lang="en">Kiseleva T.N., Kataev M.G., Il’ina N.V. et al. Ultrasonography in normal eyelids assessment. Russian Annals of Ophthalmology. 2014; 130 (1): 46–51. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chandra P., Sudhalkar A., Jalali S. et al. Echographic study of extraocular muscle thickness in normal Indian population. Saudi J. Ophthalmol. 2014; 28 (4): 281–286. https://doi.org/10.1016/j.sjopt.2014.05.003</mixed-citation><mixed-citation xml:lang="en">Chandra P., Sudhalkar A., Jalali S. et al. Echographic study of extraocular muscle thickness in normal Indian population. Saudi J. Ophthalmol. 2014; 28 (4): 281–286. https://doi.org/10.1016/j.sjopt.2014.05.003</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Surve A., Meel R., Pushker N., Bajaj M.S. Ultrasound biomicroscopy image patterns in normal upper eyelid and congenital ptosis in the Indian population. Indian J Ophthalmol. 2018; 3: 383–388. https://doi.org/10.4103/ijo.IJO_915_17</mixed-citation><mixed-citation xml:lang="en">Surve A., Meel R., Pushker N., Bajaj M.S. Ultrasound biomicroscopy image patterns in normal upper eyelid and congenital ptosis in the Indian population. Indian J Ophthalmol. 2018; 3: 383–388. https://doi.org/10.4103/ijo.IJO_915_17</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lee H.-S., Lew H., Yun Y.-S. Ultrasonographic Measurement of Upper Eyelid Thickness in Korean Children with Epicanthus. Korean J. Ophthalmol. 2006; 2: 79–81. https://doi.org/10.3341/kjo.2006.20.2.79</mixed-citation><mixed-citation xml:lang="en">Lee H.-S., Lew H., Yun Y.-S. Ultrasonographic Measurement of Upper Eyelid Thickness in Korean Children with Epicanthus. Korean J. Ophthalmol. 2006; 2: 79–81. https://doi.org/10.3341/kjo.2006.20.2.79</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Качкинбаев И.К., Алыбаев М.Э., Нгуен Д.Б. Клинико-анатомическая классификация азиатских век по сагиттальному срезу и ее роль в выборе тактики оперативного вмешательства на верхнем веке. Пластическая хирургия и эстетическая медицина. 2021; 4: 29–37. https://doi.org/10.17116/plast.hirurgia202104129</mixed-citation><mixed-citation xml:lang="en">Kachkinbaev I.K., Alybaev M.E., Nguyen D.B. Clinical and anatomical classification of Asian eyelids by sagittal slice and its role in the choice of upper eyelid surgery. Plastic Surgery and Aesthetic Medicine. 2021; 4: 29–37. https://doi.org/10.17116/plast.hirurgia202104129 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mupas-Uy J., Kitaguchi Y., Takahashi Y., Kakizaki H. Age-related eyelid changes. J. Cosmet. Med. 2017; 1(1): 16–24.</mixed-citation><mixed-citation xml:lang="en">Mupas-Uy J., Kitaguchi Y., Takahashi Y., Kakizaki H. Age-related eyelid changes. J. Cosmet. Med. 2017; 1(1): 16–24.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Windhager S., Mitteroecker P., Rupić I. Facial aging trajectories: A common shape pattern in male and female faces is disrupted after menopause. American journal of physical anthropology. 2019; 4: 678–688. https://doi.org/10.1002/ajpa.23878</mixed-citation><mixed-citation xml:lang="en">Windhager S., Mitteroecker P., Rupić I. Facial aging trajectories: A common shape pattern in male and female faces is disrupted after menopause. American journal of physical anthropology. 2019; 4: 678–688. https://doi.org/10.1002/ajpa.23878</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Okuda I., Irimoto M., Nakajima Y. et al. Using multidetector row computed tomography to evaluate baggy eyelid. Aesthetic Plast Surg. 2012; 2: 290–294. https://doi.org/10.1007/s00266-011-9829-2</mixed-citation><mixed-citation xml:lang="en">Okuda I., Irimoto M., Nakajima Y. et al. Using multidetector row computed tomography to evaluate baggy eyelid. Aesthetic Plast Surg. 2012; 2: 290–294. https://doi.org/10.1007/s00266-011-9829-2</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cho W.K., Paik J.S., Han S.H., Yang S.W. Microscopic characteristics of lower eyelid retractors in Koreans. Korean J. Ophthalmol. 2011; 5: 344–348. https://doi.org/10.3341/kjo.2011.25.5.344</mixed-citation><mixed-citation xml:lang="en">Cho W.K., Paik J.S., Han S.H., Yang S.W. Microscopic characteristics of lower eyelid retractors in Koreans. Korean J. Ophthalmol. 2011; 5: 344–348. https://doi.org/10.3341/kjo.2011.25.5.344</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Geifman N., Cohen R., Rubin E. Redefining meaningful age groups in the context of disease. Age (Dordr.). 2013; 6: 2357–2366. https://doi.org/10.1007/s11357-013-9510-6</mixed-citation><mixed-citation xml:lang="en">Geifman N., Cohen R., Rubin E. Redefining meaningful age groups in the context of disease. Age (Dordr.). 2013; 6: 2357–2366. https://doi.org/10.1007/s11357-013-9510-6</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
